Apetala 2

Not to be confused with AP2 adaptors.
AP2 domain
Structure of the GCC-box binding domain in complex with DNA.[1]
Identifiers
SymbolAP2
PfamPF00847
Pfam clanCL0081
InterProIPR001471
SMARTSM00380
PROSITEPS51032
SCOP23gcc / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1GCC​, 2GCC​, 3GCC​
Apetala 2
Identifiers
SymbolAP2
NCBI gene829845
UniProtP47927
Search for
StructuresSwiss-model
DomainsInterPro

Apetala 2 (AP2) is a gene and a member of a large family of transcription factors, the AP2/EREBP family. In Arabidopsis thaliana AP2 plays a role in the ABC model of flower development.[2] It was originally thought that this family of proteins was plant-specific; however, recent studies have shown that apicomplexans, including the causative agent of malaria, Plasmodium falciparum encode a related set of transcription factors, called the ApiAP2 family.[3]

In the A. thaliana transcription factor RAV1 the N-terminal AP2 domain binds 5'-CAACA-3' sequence, while the C-terminal highly conserved B3 domain binds 5'-CACCTG-3' sequence.[4]

  1. ^ Allen MD, Yamasaki K, Ohme-Takagi M, Tateno M, Suzuki M (September 1998). "A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA". EMBO J. 17 (18): 5484–96. doi:10.1093/emboj/17.18.5484. PMC 1170874. PMID 9736626.
  2. ^ Riechmann JL, Meyerowitz EM (1998). "The AP2/EREBP family of plant transcription factors". Biol. Chem. 379 (6): 633–46. doi:10.1515/bchm.1998.379.6.633. PMID 9687012.
  3. ^ Balaji S, Babu MM, Iyer LM, Aravind L (2005). "Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains". Nucleic Acids Research. 33 (13): 3994–4006. doi:10.1093/nar/gki709. PMC 1178005. PMID 16040597.
  4. ^ Kagaya Y, Ohmiya K, Hattori T (1999). "RAV1, a novel DNA-binding protein, binds to bipartite recognition sequence through two distinct DNA-binding domains uniquely found in higher plants". Nucleic Acids Res. 27 (2): 470–8. doi:10.1093/nar/27.2.470. PMC 148202. PMID 9862967.