An apical dendrite is a dendrite that emerges from the apex of a pyramidal cell.[1] Apical dendrites are one of two primary categories of dendrites, and they distinguish the pyramidal cells from spiny stellate cells in the cortices. Pyramidal cells are found in the prefrontal cortex, the hippocampus, the entorhinal cortex, the olfactory cortex, and other areas.[2] Dendrite arbors formed by apical dendrites are the means by which synaptic inputs into a cell are integrated.[3] The apical dendrites in these regions contribute significantly to memory, learning, and sensory associations by modulating the excitatory and inhibitory signals received by the pyramidal cells.