Apolipoprotein AI

APOA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AV1, 1GW3, 1GW4, 1ODP, 1ODQ, 1ODR, 2A01, 3K2S, 3R2P, 2MSC, 2MSD, 2MSE, 4V6M
Identifiers
Aliases	APOA1, entrez:335, apo(a), apolipoprotein A1, Apolipoprotein A-I, HPALP2
External IDs	OMIM: 107680; MGI: 88049; HomoloGene: 47900; GeneCards: APOA1; OMA:APOA1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 116,835,751 bp[1] End 116,837,622 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 25.36 cM Start 46,139,878 bp[2] End 46,141,764 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa right lobe of liver mucosa of ileum right testis left testis duodenum apex of heart gonad left ventricle amniotic fluid Top expressed in left lobe of liver jejunum yolk sac duodenum epithelium of stomach gallbladder ileum fetal liver hematopoietic progenitor cell migratory enteric neural crest cell mucous cell of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipase inhibitor activity phosphatidylcholine binding apolipoprotein receptor binding high-density lipoprotein particle receptor binding lipoprotein particle binding phosphatidylcholine-sterol O-acyltransferase activator activity phospholipid binding apolipoprotein A-I receptor binding enzyme binding cholesterol transfer activity amyloid-beta binding phospholipid transporter activity protein binding chemorepellent activity lipid transporter activity cholesterol binding identical protein binding high-density lipoprotein particle binding lipid binding heat shock protein binding signaling receptor binding Cellular component cytosol endoplasmic reticulum lumen chylomicron extracellular region nucleus extracellular vesicle endocytic vesicle lumen discoidal high-density lipoprotein particle very-low-density lipoprotein particle cell surface secretory granule lumen extracellular exosome blood microparticle endocytic vesicle plasma membrane spherical high-density lipoprotein particle early endosome high-density lipoprotein particle cytoplasmic vesicle extracellular space low-density lipoprotein particle intermediate-density lipoprotein particle collagen-containing extracellular matrix Biological process positive regulation of Rho protein signal transduction regulation of protein phosphorylation cholesterol import lipid transport negative chemotaxis positive regulation of cholesterol esterification phospholipid efflux phospholipid transport negative regulation of hydrolase activity receptor-mediated endocytosis retinoid metabolic process negative regulation of lipase activity regulation of intestinal cholesterol absorption negative regulation of cell adhesion molecule production peripheral nervous system axon regeneration endothelial cell proliferation animal organ regeneration peptidyl-methionine modification cholesterol homeostasis negative regulation of heterotypic cell-cell adhesion transforming growth factor beta receptor signaling pathway negative regulation of inflammatory response phospholipid homeostasis ERK1 and ERK2 cascade negative regulation of cytokine production involved in immune response positive regulation of fatty acid biosynthetic process high-density lipoprotein particle clearance lipoprotein metabolic process G protein-coupled receptor signaling pathway positive regulation of triglyceride catabolic process response to nutrient glucocorticoid metabolic process lipid storage protein stabilization positive regulation of lipoprotein lipase activity cholesterol metabolic process response to estrogen triglyceride catabolic process transmembrane transport transport cholesterol efflux integrin-mediated signaling pathway phosphatidylcholine biosynthetic process neuron projection regeneration negative regulation of very-low-density lipoprotein particle remodeling steroid metabolic process positive regulation of hydrolase activity regulation of Cdc42 protein signal transduction blood vessel endothelial cell migration negative regulation of tumor necrosis factor-mediated signaling pathway lipid metabolism cholesterol transport platelet degranulation adrenal gland development high-density lipoprotein particle assembly negative regulation of response to cytokine stimulus high-density lipoprotein particle remodeling positive regulation of substrate adhesion-dependent cell spreading phospholipid metabolic process vitamin transport cholesterol biosynthetic process positive regulation of stress fiber assembly triglyceride homeostasis reverse cholesterol transport lipoprotein biosynthetic process positive regulation of cholesterol efflux regulation of lipid metabolic process regulation of cholesterol transport chylomicron remodeling very-low-density lipoprotein particle remodeling chylomicron assembly post-translational protein modification positive regulation of lipid biosynthetic process positive regulation of phagocytosis positive regulation of phospholipid efflux Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 335 11806 Ensembl ENSG00000118137 ENSMUSG00000032083 UniProt P02647 Q00623 RefSeq (mRNA) NM_000039 NM_001318017 NM_001318018 NM_001318021 NM_009692 RefSeq (protein) NP_000030 NP_001304946 NP_001304947 NP_001304950 NP_000030.1 NP_001304946.1 NP_001304947.1 NP_033822 Location (UCSC) Chr 11: 116.84 – 116.84 Mb Chr 9: 46.14 – 46.14 Mb PubMed search [3] [4]
Wikidata
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Apolipoprotein AI (Apo-AI) is a protein that in humans is encoded by the APOA1 gene.^[5][6] As the major component of HDL particles, it has a specific role in lipid metabolism.