Apolipoprotein B

APOB
Identifiers
Aliases	APOB, FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B, FCHL2
External IDs	OMIM: 107730; MGI: 88052; HomoloGene: 328; GeneCards: APOB; OMA:APOB - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.1 Start 21,001,429 bp[1] End 21,044,073 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.1|12 3.53 cM Start 8,027,648 bp[2] End 8,066,835 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa liver mucosa of ileum right lobe of liver duodenum right ventricle right auricle myocardium left ventricle cardiac muscle tissue of right atrium Top expressed in left lobe of liver jejunum yolk sac duodenum ileum gallbladder primitive streak intestinal epithelium intestinal villus migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding lipid transporter activity cholesterol transfer activity lipase binding low-density lipoprotein particle receptor binding phospholipid binding heparin binding signaling receptor binding Cellular component early endosome chylomicron remnant vesicle lumen endoplasmic reticulum endosome membrane mature chylomicron endoplasmic reticulum lumen vesicle membrane endosome lumen intermediate-density lipoprotein particle clathrin-coated endocytic vesicle membrane endoplasmic reticulum membrane extracellular exosome endocytic vesicle lumen soma cytoplasm chylomicron very-low-density lipoprotein particle low-density lipoprotein particle endoplasmic reticulum exit site extracellular space smooth endoplasmic reticulum cytosol plasma membrane lysosomal lumen intracellular membrane-bounded organelle extracellular region high-density lipoprotein particle Biological process artery morphogenesis in utero embryonic development fertilization receptor-mediated endocytosis positive regulation of cholesterol storage lipid metabolism cholesterol metabolic process cholesterol transport regulation of cholesterol biosynthetic process lipid transport nervous system development leukocyte migration response to carbohydrate retinoid metabolic process steroid metabolic process triglyceride mobilization lipid catabolic process response to lipopolysaccharide positive regulation of macrophage derived foam cell differentiation cellular response to prostaglandin stimulus response to virus positive regulation of lipid storage cellular response to tumor necrosis factor response to selenium ion flagellated sperm motility positive regulation of gene expression response to organic substance cholesterol homeostasis spermatogenesis triglyceride catabolic process cholesterol efflux post-embryonic development lipoprotein transport toll-like receptor signaling pathway response to estradiol membrane organization chylomicron remodeling low-density lipoprotein particle remodeling chylomicron assembly very-low-density lipoprotein particle assembly chylomicron remnant clearance low-density lipoprotein particle clearance very-low-density lipoprotein particle clearance lipoprotein metabolic process lipoprotein biosynthetic process lipoprotein catabolic process post-translational protein modification transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338 238055 Ensembl ENSG00000084674 ENSMUSG00000020609 UniProt P04114 E9Q414 RefSeq (mRNA) NM_000384 NM_009693 RefSeq (protein) NP_000375 NP_033823 Location (UCSC) Chr 2: 21 – 21.04 Mb Chr 12: 8.03 – 8.07 Mb PubMed search [3] [4]
Wikidata
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Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. Its measurement is commonly used to detect risk of atherosclerotic cardiovascular disease.^[5][6]