Apple of Sodom (Calotropis procera) is a species of milkweed in the family Apocynaceae native to the Dead Sea and Sodom, Israel and other desert regions.
Apple of Sodom may also refer to:
Solanum carolinense or Carolina horsenettle, a nightshade native to North America
Solanum linnaeanum or devil's apple, formerly Solanum sodomeum, an invasive nightshade native to South Africa
Solanum mammosum or nipplefruit, a nightshade native to South America