Aquaporin-8

AQP8
Identifiers
Aliases	AQP8, AQP-8, aquaporin 8
External IDs	OMIM: 603750; MGI: 1195271; HomoloGene: 68166; GeneCards: AQP8; OMA:AQP8 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	25,228,932 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	123,067,227 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; body of pancreas; ; mucosa of ileum; ; rectum; ; mucosa of sigmoid colon; ; testicle; ; pancreatic epithelial cell; ; epithelium of colon; ; islet of Langerhans; ; cerebellar hemisphere;
	Top expressed in
	left colon; ; left lobe of liver; ; lacrimal gland; ; spermatocyte; ; blastocyst; ; yolk sac; ; embryo; ; parotid gland; ; seminiferous tubule; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	water channel activity; channel activity;
Cellular component	integral component of membrane; plasma membrane; apical part of cell; integral component of plasma membrane; membrane; mitochondrion; mitochondrial membranes;
Biological process	ion transmembrane transport; cellular response to cAMP; water transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	343
	11833
	ENSG00000103375
	ENSMUSG00000030762
	O94778
	P56404
	NM_001169
	NM_001109045; NM_007474
	NP_001160
	NP_001102515; NP_031500
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene.^[5]^[6]^[7]

Aquaporin-8 (AQP-8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-8 mRNA is found in pancreas and colon but not other tissues.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103375 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030762 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Koyama N, Ishibashi K, Kuwahara M, Inase N, Ichioka M, Sasaki S, Marumo F (Jan 1999). "Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene". Genomics. 54 (1): 169–72. doi:10.1006/geno.1998.5552. PMID 9806845.
^ Viggiano L, Rocchi M, Svelto M, Calamita G (Jul 1999). "Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12". Cytogenet Cell Genet. 84 (3–4): 208–10. doi:10.1159/000015260. PMID 10393433. S2CID 23854978.
^ ^a ^b "Entrez Gene: AQP8 aquaporin 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103375 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030762 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806845-5] Koyama N, Ishibashi K, Kuwahara M, Inase N, Ichioka M, Sasaki S, Marumo F (Jan 1999). "Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene". Genomics. 54 (1): 169–72. doi:10.1006/geno.1998.5552. PMID 9806845.

[pmid10393433-6] Viggiano L, Rocchi M, Svelto M, Calamita G (Jul 1999). "Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12". Cytogenet Cell Genet. 84 (3–4): 208–10. doi:10.1159/000015260. PMID 10393433. S2CID 23854978.

[entrez-7] "Entrez Gene: AQP8 aquaporin 8".

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