Archaeal transcription factor B

Transcription factor II B
Crystallographic structure of transcription factor II B (top; rainbow colored, N-terminus = blue, C-terminus = red) complexed with double stranded DNA (bottom).
Identifiers
OrganismPyrococcus woesei
Symboltfb
PDB1d3u
UniProtP61999
Search for
StructuresSwiss-model
DomainsInterPro

Archaeal transcription factor B (ATFB or TFB) is a protein family of extrinsic transcription factors that guide the initiation of RNA transcription in organisms that fall under the domain of Archaea.[1] It is homologous to eukaryotic TFIIB and, more distantly, to bacterial sigma factor.[2] Like these proteins, it is involved in forming transcription preinitiation complexes.[3] Its structure includes several conserved motifs which interact with DNA and other transcription factors, notably the single type of RNA polymerase that performs transcription in Archaea.[1]

  1. ^ a b Micorescu M, Grünberg S, Franke A, Cramer P, Thomm M, Bartlett M (January 2008). "Archaeal transcription: function of an alternative transcription factor B from Pyrococcus furiosus". Journal of Bacteriology. 190 (1): 157–67. doi:10.1128/JB.01498-07. PMC 2223750. PMID 17965161.
  2. ^ Burton SP, Burton ZF (6 November 2014). "The σ enigma: bacterial σ factors, archaeal TFB and eukaryotic TFIIB are homologs". Transcription. 5 (4): e967599. doi:10.4161/21541264.2014.967599. PMC 4581349. PMID 25483602.
  3. ^ Soppa J (March 1999). "Transcription initiation in Archaea: facts, factors and future aspects". Molecular Microbiology. 31 (5): 1295–305. doi:10.1046/j.1365-2958.1999.01273.x. PMID 10200952.