Artemether/lumefantrine

Artemether/lumefantrine
Combination of
ArtemetherAntimalarial
LumefantrineAntimalarial
Clinical data
Trade namesCoartem, Riamet, Falcynate-LF
AHFS/Drugs.comMonograph
MedlinePlusa609024
Pregnancy
category
  • AU: D
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
ChemSpider
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Artemether/lumefantrine, sold under the trade name Coartem among others, is a combination of the two medications artemether and lumefantrine.[1] It is used to treat malaria caused by Plasmodium falciparum that is not treatable with chloroquine.[1] It is not typically used to prevent malaria.[1] It is taken by mouth.[1]

Common side effects include muscle and joint pains, fever, loss of appetite, and headache.[1] Serious side effects include prolongation of the QT interval.[1] While not well studied, it appears to be safe for use in pregnancy.[1] The dose does not need changing in those with mild or moderate kidney or liver problems.[1]

This combination came into medical use in 1992[2] and was developed in China.[2][3] It is on the World Health Organization's List of Essential Medicines.[4] It is not available as a generic medication.[5]

  1. ^ a b c d e f g h "Artemether and Lumefantrine". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-08. Retrieved Dec 2, 2015.
  2. ^ a b Ravina, Enrique (2011). The evolution of drug discovery : from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 139. ISBN 9783527326693. Archived from the original on 2015-12-08.
  3. ^ Nightingale, Charles H. (2007). Antimicrobial pharmacodynamics in theory and clinical practice (2nd ed.). New York: Informa Healthcare. p. 380. ISBN 9781420017137. Archived from the original on 2015-12-08.
  4. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  5. ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 45. ISBN 9781284057560.