Arterial spin labelling

Arterial spin labeling (ASL), also known as arterial spin tagging, is a magnetic resonance imaging technique used to quantify cerebral blood perfusion by labelling blood water as it flows throughout the brain. ASL specifically refers to magnetic labeling of arterial blood below or in the imaging slab, without the need of gadolinium contrast.[1] A number of ASL schemes are possible, the simplest being flow alternating inversion recovery (FAIR) which requires two acquisitions of identical parameters with the exception of the out-of-slice saturation; the difference in the two images is theoretically only from inflowing spins, and may be considered a 'perfusion map'.[2] The ASL technique was developed by John S. Leigh Jr, John A. Detre, Donald S. Williams, and Alan P. Koretsky in 1992.[3][4][5][6]

  1. ^ Fortin F, Gaillard F. "Arterial spin labelling (ASL) MR perfusion". Radiopaedia. Retrieved 2017-10-15.
  2. ^ "Arterial spin labeling". University of Michigan. Retrieved 2017-10-27.
  3. ^ Williams, D. S.; Detre, J. A.; Leigh, J. S.; Koretsky, A. P. (1992-01-01). "Magnetic resonance imaging of perfusion using spin inversion of arterial water". Proceedings of the National Academy of Sciences. 89 (1): 212–216. Bibcode:1992PNAS...89..212W. doi:10.1073/pnas.89.1.212. ISSN 0027-8424. PMC 48206. PMID 1729691.
  4. ^ Detre, John A.; Leigh, John S.; Williams, Donald S.; Koretsky, Alan P. (January 1992). "Perfusion imaging". Magnetic Resonance in Medicine. 23 (1): 37–45. doi:10.1002/mrm.1910230106. ISSN 0740-3194. PMID 1734182. S2CID 260421572.
  5. ^ Leigh, J.S., Detre, J.A., Williams, D.S., Koretsky, A.P. "Methods for measuring perfusion using magnetic resonance imaging" US Patent No. 5,402,785 (1995).
  6. ^ Koretsky AP (August 2012). "Early development of arterial spin labeling to measure regional brain blood flow by MRI". NeuroImage. 62 (2): 602–7. doi:10.1016/j.neuroimage.2012.01.005. PMC 4199083. PMID 22245338.