Asthma phenotyping and endotyping

Asthma phenotyping and endotyping is a novel approach to asthma classification inspired by precision medicine. It seeks to separate the clinical presentations or clusters of signs and symptoms of asthma, known as asthma phenotypes, from their underlying etiologies or causes, known as asthma endotypes.[1][2][3]

Asthma endotyping is useful in predicting which patients will benefit from inhaled corticosteroids or targeted therapy using specific biologics, while phenotyping can help predict disease outcomes. Numerous asthma phenotypes and endotypes have been proposed, though not all have been validated or widely accepted.[1][2][3]

  1. ^ a b Kuruvilla, Merin E.; Lee, F. Eun-Hyung; Lee, Gerald B. (April 2019). "Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease". Clinical Reviews in Allergy & Immunology. 56 (2): 219–233. doi:10.1007/s12016-018-8712-1. ISSN 1080-0549. PMC 6411459. PMID 30206782.
  2. ^ a b Ray, Anuradha; Camiolo, Matthew; Fitzpatrick, Anne; Gauthier, Marc; Wenzel, Sally E. (2020-07-01). "Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma?". Physiological Reviews. 100 (3): 983–1017. doi:10.1152/physrev.00023.2019. ISSN 0031-9333. PMC 7474260. PMID 31917651.
  3. ^ a b Cite error: The named reference :6 was invoked but never defined (see the help page).