| Combination of | |
|---|---|
| Atovaquone | Antimalarial medication |
| Proguanil | Antimalarial medication |
| Clinical data | |
| Trade names | Malarone, Malanil, others |
| AHFS/Drugs.com | Monograph |
| License data | |
| Pregnancy category |
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| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
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Atovaquone/proguanil, sold under the brand name Malarone among others, is a fixed-dose combination medication used to treat and prevent malaria, including chloroquine-resistant malaria.[2][3] It contains atovaquone and proguanil.[3] It is not recommended for severe or complicated malaria.[3] It is taken by mouth.[3]
Common side effects include abdominal pain, vomiting, diarrhea, cough, and itchiness.[3] Serious side effects may include anaphylaxis, Stevens–Johnson syndrome, hallucinations, and liver problems.[3][4] Side effects are generally mild.[5] It is unclear if use during pregnancy or breastfeeding is safe for the baby.[6] It is not recommended to prevent malaria in those with poor kidney function.[4] Atovaquone works by interfering with the function of mitochondria in malaria while proguanil blocks dihydrofolate reductase.[3]
Atovaquone/proguanil was approved for medical use in the United States in 2000.[3] It has been available as a generic medication since 2011.[7]
- ^ "Atovaquopro Lupin (Generic Health Pty Ltd)". Therapeutic Goods Administration (TGA). 28 September 2022. Archived from the original on 12 October 2022. Retrieved 29 April 2023.
- ^ Nakato H, Vivancos R, Hunter PR (November 2007). "A systematic review and meta-analysis of the effectiveness and safety of atovaquone proguanil (Malarone) for chemoprophylaxis against malaria". The Journal of Antimicrobial Chemotherapy. 60 (5): 929–936. doi:10.1093/jac/dkm337. PMID 17848375.
- ^ a b c d e f g h "Atovaquone and Proguanil Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 12 September 2019.
- ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 604. ISBN 9780857113382.
- ^ Cite error: The named reference
Drug2019Sidewas invoked but never defined (see the help page). - ^ "Atovaquone / proguanil Use During Pregnancy". Drugs.com. Archived from the original on 16 August 2019. Retrieved 12 September 2019.
- ^ "Generic Malarone Availability". Drugs.com. Archived from the original on 16 August 2019. Retrieved 12 September 2019.