Aurora kinase A

AURKA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UZH, 1MQ4, 1MUO, 1OL5, 1OL6, 1OL7, 2BMC, 2C6D, 2C6E, 2DWB, 2J4Z, 2J50, 2NP8, 2W1C, 2W1D, 2W1E, 2W1F, 2W1G, 2WQE, 2WTV, 2WTW, 2X6D, 2X6E, 2X81, 2XNE, 2XNG, 2XRU, 3COH, 3E5A, 3EFW, 3FDN, 3H0Y, 3H0Z, 3H10, 3HA6, 3K5U, 3LAU, 3M11, 3MYG, 3NRM, 3O50, 3O51, 3P9J, 3QBN, 3R21, 3R22, 3UNZ, 3UO4, 3UO5, 3UO6, 3UOD, 3UOH, 3UOJ, 3UOK, 3UOL, 3UP2, 3UP7, 3VAP, 3W10, 3W16, 3W18, 3W2C, 4B0G, 4BN1, 4BYI, 4BYJ, 4C3P, 4C3R, 4CEG, 4DEA, 4DEB, 4DED, 4DEE, 4DHF, 4J8M, 4J8N, 4JAI, 4JAJ, 4JBO, 4JBP, 4JBQ, 4O0S, 4O0U, 4O0W, 4PRJ, 4UYN, 4UZD, 4UTD, 5AAD, 5AAE, 5AAF, 5AAG, 5EW9, 5DR9, 5DPV, 5DN3, 5DRD, 5L8J, 4ZS0, 5DR6
Identifiers
Aliases	AURKA, AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, aurora kinase A
External IDs	OMIM: 603072; MGI: 894678; HomoloGene: 2670; GeneCards: AURKA; OMA:AURKA - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	56,392,337 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	172,212,455 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ventricular zone; ; sperm; ; gonad; ; trabecular bone; ; embryo; ; ganglionic eminence; ; amniotic fluid; ; testicle;
	Top expressed in
	secondary oocyte; ; zygote; ; morula; ; otic vesicle; ; morula; ; seminiferous tubule; ; otic placode; ; fetal liver hematopoietic progenitor cell; ; epiblast; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; ATP binding; protein kinase binding; ubiquitin protein ligase binding; protein serine/threonine kinase activity; histone serine kinase activity; protein kinase activity; protein heterodimerization activity;
Cellular component	cytoplasm; germinal vesicle; cell projection; spindle pole; microtubule cytoskeleton; meiotic spindle; spindle pole centrosome; cilium; microtubule organizing center; chromosome passenger complex; midbody; spindle microtubule; spindle midzone; perinuclear region of cytoplasm; axon hillock; pronucleus; centriole; mitotic spindle; cytoskeleton; nucleus; microtubule; centrosome; nucleoplasm; spindle; cytosol; mitotic spindle pole;
Biological process	regulation of cytokinesis; regulation of protein stability; phosphorylation; positive regulation of oocyte maturation; centrosome localization; negative regulation of apoptotic process; negative regulation of protein binding; neuron projection extension; cell division; regulation of centrosome cycle; cell projection organization; G2/M transition of mitotic cell cycle; meiotic spindle organization; mitotic centrosome separation; protein autophosphorylation; anaphase-promoting complex-dependent catabolic process; protein localization to centrosome; cell cycle; anterior/posterior axis specification; positive regulation of mitotic nuclear division; spindle assembly involved in female meiosis I; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; microtubule cytoskeleton organization; regulation of signal transduction by p53 class mediator; spindle organization; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; mitotic spindle organization; protein phosphorylation; response to wounding; negative regulation of G2/M transition of mitotic cell cycle; liver regeneration; meiosis; mitotic cell cycle; centrosome cycle; regulation of G2/M transition of mitotic cell cycle; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6790
	20878
	ENSG00000087586
	ENSMUSG00000027496
	O14965
	P97477
NM_003600; NM_198433; NM_198434; NM_198435; NM_198436;
	NM_198437; NM_001323303; NM_001323304; NM_001323305
	NM_011497; NM_001291185
NP_001310232; NP_001310233; NP_001310234; NP_003591; NP_940835;
	NP_940836; NP_940837; NP_940838; NP_940839
	NP_001278114; NP_035627
	Wikidata
View/Edit Human	View/Edit Mouse

Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.^[5]^[6]

Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations^[7] and its activity peaks during the G2 phase to M phase transition in the cell cycle.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087586 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027496 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sen S, Zhou H, White RA (May 1997). "A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines". Oncogene. 14 (18): 2195–200. doi:10.1038/sj.onc.1201065. PMID 9174055.
^ Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S (October 1998). "Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation". Nat. Genet. 20 (2): 189–93. doi:10.1038/2496. PMID 9771714. S2CID 40012197.
^ Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV (2004). "Aurora A, meiosis and mitosis". Biol. Cell. 96 (3): 215–29. doi:10.1016/j.biolcel.2003.09.008. PMID 15182704. S2CID 29416056.
^ Hannak E, Kirkham M, Hyman AA, Oegema K (December 2001). "Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans". J. Cell Biol. 155 (7): 1109–16. doi:10.1083/jcb.200108051. PMC 2199344. PMID 11748251.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087586 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027496 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9174055-5] Sen S, Zhou H, White RA (May 1997). "A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines". Oncogene. 14 (18): 2195–200. doi:10.1038/sj.onc.1201065. PMID 9174055.

[pmid9771714-6] Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S (October 1998). "Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation". Nat. Genet. 20 (2): 189–93. doi:10.1038/2496. PMID 9771714. S2CID 40012197.

[Crane_2004-7] Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV (2004). "Aurora A, meiosis and mitosis". Biol. Cell. 96 (3): 215–29. doi:10.1016/j.biolcel.2003.09.008. PMID 15182704. S2CID 29416056.

[Hannak_2001-8] Hannak E, Kirkham M, Hyman AA, Oegema K (December 2001). "Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans". J. Cell Biol. 155 (7): 1109–16. doi:10.1083/jcb.200108051. PMC 2199344. PMID 11748251.

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