Aurora kinase B

AURKB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AF3
Identifiers
Aliases	AURKB, AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5, aurkb-sv1, aurkb-sv2, aurora kinase B, STK-1, ARK-2
External IDs	OMIM: 604970; MGI: 107168; HomoloGene: 55807; GeneCards: AURKB; OMA:AURKB - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,210,600 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	68,942,490 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; oocyte; ; gonad; ; mucosa of transverse colon; ; tibial nerve; ; stromal cell of endometrium; ; sural nerve; ; rectum; ; bone marrow;
	Top expressed in
	tail of embryo; ; genital tubercle; ; yolk sac; ; otic placode; ; otic vesicle; ; ventricular zone; ; abdominal wall; ; somite; ; epiblast; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; histone serine kinase activity; metal ion binding; kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; ATP binding; protein serine/threonine kinase activity; kinase binding;
Cellular component	cytoplasm; cytosol; spindle; spindle pole centrosome; nucleoplasm; chromosome; chromosome passenger complex; midbody; spindle microtubule; spindle midzone; chromocenter; chromosome, centromeric region; cytoskeleton; nucleus; kinetochore; condensed chromosome, centromeric region; mitotic spindle midzone;
Biological process	abscission; cleavage furrow formation; positive regulation of telomere capping; phosphorylation; mitotic spindle midzone assembly; histone modification; cellular response to UV; human ageing; positive regulation of telomere maintenance via telomerase; negative regulation of transcription by RNA polymerase II; negative regulation of protein binding; positive regulation of cytokinesis; regulation of chromosome segregation; cell division; protein phosphorylation; spindle checkpoint signaling; positive regulation of telomerase activity; protein autophosphorylation; negative regulation of B cell apoptotic process; negative regulation of cytokinesis; anaphase-promoting complex-dependent catabolic process; cell cycle; cell population proliferation; attachment of spindle microtubules to kinetochore; protein localization to kinetochore; spindle organization; regulation of signal transduction by p53 class mediator; mitotic cell cycle; mitotic cytokinesis checkpoint signaling; mitotic spindle organization; mitotic spindle assembly checkpoint signaling; regulation of cytokinesis; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9212
	20877
	ENSG00000178999
	ENSMUSG00000020897
	Q96GD4
	O70126
NM_001313950; NM_001313951; NM_001313952; NM_001313953; NM_001313954;
	NM_001313955; NM_001256834; NM_001284526; NM_004217
	NM_011496
NP_001243763; NP_001271455; NP_001300879; NP_001300880; NP_001300881;
	NP_001300882; NP_001300883; NP_001300884; NP_004208
	NP_035626
	Wikidata
View/Edit Human	View/Edit Mouse

Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere and in cytokinesis.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178999 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020897 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178999 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020897 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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