Autotaxin

ENPP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZGA, 4ZG6, 4ZG9, 4ZG7
Identifiers
Aliases	ENPP2, ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
External IDs	OMIM: 601060; MGI: 1321390; HomoloGene: 4526; GeneCards: ENPP2; OMA:ENPP2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	119,673,453 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	54,952,892 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; Epithelium of choroid plexus; ; inferior ganglion of vagus nerve; ; corpus callosum; ; endothelial cell; ; subthalamic nucleus; ; pons; ; superior vestibular nucleus; ; middle frontal gyrus; ; external globus pallidus;
	Top expressed in
	Epithelium of choroid plexus; ; retinal pigment epithelium; ; fourth ventricle; ; choroid plexus of fourth ventricle; ; deep cerebellar nuclei; ; iris; ; mesenteric lymph nodes; ; globus pallidus; ; nucleus of stria terminalis; ; habenula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide diphosphatase activity; phosphodiesterase I activity; transcription factor binding; polysaccharide binding; metal ion binding; scavenger receptor activity; catalytic activity; alkylglycerophosphoethanolamine phosphodiesterase activity; nucleic acid binding; hydrolase activity; calcium ion binding; lysophospholipase activity; zinc ion binding;
Cellular component	plasma membrane; integral component of plasma membrane; extracellular region; extracellular space; cytoplasm; Golgi apparatus;
Biological process	G protein-coupled receptor signaling pathway; regulation of cell migration; positive regulation of lamellipodium morphogenesis; lipid metabolism; positive regulation of epithelial cell migration; regulation of angiogenesis; receptor-mediated endocytosis; lipid catabolic process; immune response; phospholipid catabolic process; positive regulation of peptidyl-tyrosine phosphorylation; phosphate-containing compound metabolic process; metabolism; chemotaxis; phosphatidylcholine catabolic process; nucleic acid phosphodiester bond hydrolysis; cell motility; phospholipid metabolic process; negative regulation of cell-matrix adhesion; positive regulation of cell population proliferation; diencephalon development; forebrain development; midbrain development; positive regulation of oligodendrocyte differentiation; positive regulation of focal adhesion assembly; cell chemotaxis; cellular response to cadmium ion; cellular response to estradiol stimulus; positive regulation of substrate adhesion-dependent cell spreading; response to polycyclic arene; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	5168
	18606
	ENSG00000136960
	ENSMUSG00000022425
	Q13822
	Q9R1E6
	NM_001040092; NM_001130863; NM_006209; NM_001330600
	NM_001136077; NM_015744; NM_001285994; NM_001285995
	NP_001035181; NP_001124335; NP_001317529; NP_006200
	NP_001129549; NP_001272923; NP_001272924; NP_056559
	Wikidata
View/Edit Human	View/Edit Mouse

Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2), is an enzyme that in humans is encoded by the ENPP2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136960 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022425 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kawagoe H, Soma O, Goji J, Nishimura N, Narita M, Inazawa J, et al. (November 1995). "Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2)". Genomics. 30 (2): 380–4. doi:10.1006/geno.1995.0036. hdl:20.500.14094/D1001481. PMID 8586446.
^ "Entrez Gene: ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136960 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022425 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8586446-5] Kawagoe H, Soma O, Goji J, Nishimura N, Narita M, Inazawa J, et al. (November 1995). "Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2)". Genomics. 30 (2): 380–4. doi:10.1006/geno.1995.0036. hdl:20.500.14094/D1001481. PMID 8586446.

[entrez-6] "Entrez Gene: ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)".

[1]

[2]

[3]

[4]

[5]

[6]