BACH1

BACH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IHC
Identifiers
Aliases	BACH1, BACH-1, BTBD24, BTB domain and CNC homolog 1
External IDs	OMIM: 602751; MGI: 894680; HomoloGene: 916; GeneCards: BACH1; OMA:BACH1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	29,630,751 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	87,530,234 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; monocyte; ; Achilles tendon; ; bone marrow cells; ; blood; ; stromal cell of endometrium; ; sperm; ; granulocyte; ; cartilage tissue; ; amniotic fluid;
	Top expressed in
	epithelium of small intestine; ; intestinal villus; ; Ileal epithelium; ; left lung lobe; ; superior cervical ganglion; ; decidua; ; conjunctival fornix; ; external carotid artery; ; medial ganglionic eminence; ; stroma of bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; ubiquitin-protein transferase activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; heme binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; Cul3-RING ubiquitin ligase complex; nucleus;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transcription involved in G1/S transition of mitotic cell cycle; transcription, DNA-templated; regulation of transcription from RNA polymerase II promoter in response to hypoxia; DNA repair; positive regulation of transcription by RNA polymerase II; regulation of transcription involved in G2/M transition of mitotic cell cycle; protein ubiquitination; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	571
	12013
	ENSG00000156273
	ENSMUSG00000025612
	O14867
	P97302
	NM_001011545; NM_001186; NM_206866
	NM_007520
	NP_001177; NP_996749
	NP_031546
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156273 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025612 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Blouin JL, Duriaux Saïl G, Guipponi M, Rossier C, Pappasavas MP, Antonarakis SE (Mar 1998). "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1". Human Genetics. 102 (3): 282–8. doi:10.1007/s004390050692. PMID 9544839. S2CID 9494442.
^ Ohira M, Seki N, Nagase T, Ishikawa K, Nomura N, Ohara O (Jan 1998). "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". Genomics. 47 (2): 300–6. doi:10.1006/geno.1997.5080. PMID 9479503.
^ "Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156273 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025612 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9544839-5] Blouin JL, Duriaux Saïl G, Guipponi M, Rossier C, Pappasavas MP, Antonarakis SE (Mar 1998). "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1". Human Genetics. 102 (3): 282–8. doi:10.1007/s004390050692. PMID 9544839. S2CID 9494442.

[pmid9479503-6] Ohira M, Seki N, Nagase T, Ishikawa K, Nomura N, Ohara O (Jan 1998). "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". Genomics. 47 (2): 300–6. doi:10.1006/geno.1997.5080. PMID 9479503.

[entrez-7] "Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1".

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