BCAR1

BCAR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WYX, 3T6G
Identifiers
Aliases	BCAR1, CAS, CAS1, CASS1, CRKAS, P130Cas, Cas family scaffolding protein, Cas family scaffold protein, BCAR1 scaffold protein, Cas family member
External IDs	OMIM: 602941; MGI: 108091; HomoloGene: 7674; GeneCards: BCAR1; OMA:BCAR1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	75,268,053 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	112,470,441 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; ascending aorta; ; gastrocnemius muscle; ; apex of heart; ; mucosa of transverse colon; ; body of stomach; ; Descending thoracic aorta; ; human kidney; ; placenta; ; pituitary gland;
	Top expressed in
	endothelial cell of lymphatic vessel; ; fossa; ; Paneth cell; ; motor neuron; ; condyle; ; retinal pigment epithelium; ; yolk sac; ; external carotid artery; ; internal carotid artery; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding; protein kinase binding; signal transducer activity;
Cellular component	cytoplasm; cytosol; focal adhesion; plasma membrane; cell junction; actin cytoskeleton; lamellipodium; ruffle;
Biological process	regulation of apoptotic process; B cell receptor signaling pathway; G protein-coupled receptor signaling pathway; insulin receptor signaling pathway; neurotrophin TRK receptor signaling pathway; epidermal growth factor receptor signaling pathway; actin filament organization; positive regulation of cell migration; cellular response to hepatocyte growth factor stimulus; antigen receptor-mediated signaling pathway; cell division; positive regulation of endothelial cell migration; vascular endothelial growth factor receptor signaling pathway; cell adhesion; regulation of cell growth; cell chemotaxis; integrin-mediated signaling pathway; platelet-derived growth factor receptor signaling pathway; cell population proliferation; T cell receptor signaling pathway; hepatocyte growth factor receptor signaling pathway; cell migration; signal transduction; actin filament reorganization;
	Sources:Amigo / QuickGO
Orthologs
	9564
	12927
	ENSG00000050820; ENSG00000285460
	ENSMUSG00000031955
	P56945
	Q61140
NM_001170714; NM_001170715; NM_001170716; NM_001170717; NM_001170718;
	NM_001170719; NM_001170720; NM_001170721; NM_014567
	NM_001198839; NM_009954
NP_001164185; NP_001164186; NP_001164187; NP_001164188; NP_001164189;
	NP_001164190; NP_001164191; NP_001164192; NP_055382
	NP_001185768; NP_034084
	Wikidata
View/Edit Human	View/Edit Mouse

Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000285460 GRCh38: Ensembl release 89: ENSG00000050820, ENSG00000285460 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031955 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dorssers LC, van Agthoven T, Dekker A, van Agthoven TL, Kok EM (Oct 1993). "Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site". Mol Endocrinol. 7 (7): 870–8. doi:10.1210/mend.7.7.8413311. PMID 8413311.
^ Brinkman A, van der Flier S, Kok EM, Dorssers LC (Feb 2000). "BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells" (PDF). J Natl Cancer Inst. 92 (2): 112–20. doi:10.1093/jnci/92.2.112. PMID 10639512.

[refGRCh38Ensembl-1] ENSG00000285460 GRCh38: Ensembl release 89: ENSG00000050820, ENSG00000285460 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031955 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8413311-5] Dorssers LC, van Agthoven T, Dekker A, van Agthoven TL, Kok EM (Oct 1993). "Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site". Mol Endocrinol. 7 (7): 870–8. doi:10.1210/mend.7.7.8413311. PMID 8413311.

[pmid10639512-6] Brinkman A, van der Flier S, Kok EM, Dorssers LC (Feb 2000). "BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells" (PDF). J Natl Cancer Inst. 92 (2): 112–20. doi:10.1093/jnci/92.2.112. PMID 10639512.

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