BMPR2

BMPR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HLQ, 3G2F
Identifiers
Aliases	BMPR2, BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK, bone morphogenetic protein receptor type 2
External IDs	OMIM: 600799; MGI: 1095407; HomoloGene: 929; GeneCards: BMPR2; OMA:BMPR2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1-q33.2 Start 202,376,327 bp[1] End 202,567,751 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C2 Start 59,802,559 bp[2] End 59,918,173 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura lower lobe of lung tendon of biceps brachii urethra lateral nuclear group of thalamus parietal pleura right lung skin of thigh skin of hip tail of epididymis Top expressed in cumulus cell ciliary body iris carotid body right lung lobe substantia nigra molar retinal pigment epithelium pineal gland epithelium of lens More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane receptor protein serine/threonine kinase activity ATP binding protein serine/threonine kinase activity activin receptor activity, type II BMP binding protein kinase activity protein binding kinase activity growth factor binding metal ion binding nucleotide binding transferase activity BMP receptor activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II SMAD binding Cellular component integral component of membrane caveola spanning component of plasma membrane dendrite neuronal cell body membrane cell surface integral component of plasma membrane plasma membrane cytoplasm basal plasma membrane apical plasma membrane extracellular space nucleoplasm postsynaptic density receptor complex Biological process endothelial cell apoptotic process positive regulation of epithelial cell migration transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of vasoconstriction positive regulation of endothelial cell proliferation endochondral bone morphogenesis positive regulation of endothelial cell migration lymphangiogenesis positive regulation of pathway-restricted SMAD protein phosphorylation anterior/posterior pattern specification regulation of cell population proliferation lung alveolus development negative regulation of cell growth transcription by RNA polymerase II regulation of lung blood pressure protein phosphorylation positive regulation of axon extension involved in axon guidance artery development blood vessel remodeling BMP signaling pathway mesoderm formation vascular endothelial growth factor receptor signaling pathway signal transduction proteoglycan biosynthetic process positive regulation of cartilage development maternal placenta development endothelial cell proliferation cellular response to starvation negative regulation of DNA biosynthetic process chondrocyte development negative regulation of systemic arterial blood pressure positive regulation of osteoblast differentiation retina vasculature development in camera-type eye cellular response to BMP stimulus phosphorylation venous blood vessel development brain development retina development in camera-type eye positive regulation of BMP signaling pathway limb development positive regulation of bone mineralization negative regulation of chondrocyte proliferation lymphatic endothelial cell differentiation mitral valve morphogenesis pharyngeal arch artery morphogenesis tricuspid valve morphogenesis outflow tract septum morphogenesis atrioventricular valve morphogenesis activin receptor signaling pathway cardiac muscle tissue development outflow tract morphogenesis endocardial cushion development negative regulation of cell proliferation involved in heart valve morphogenesis positive regulation of ossification positive regulation of transcription by RNA polymerase II ventricular septum morphogenesis atrial septum morphogenesis semi-lunar valve development transforming growth factor beta receptor signaling pathway pattern specification process aortic valve development pulmonary valve development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 659 12168 Ensembl ENSG00000204217 ENSMUSG00000067336 UniProt Q13873 O35607 RefSeq (mRNA) NM_001204 NM_033346 NM_007561 RefSeq (protein) NP_001195 NP_031587 Location (UCSC) Chr 2: 202.38 – 202.57 Mb Chr 1: 59.8 – 59.92 Mb PubMed search [3] [4]
Wikidata
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Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signaling. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell differentiation. Signaling in the BMP pathway begins with the binding of a BMP to the type II receptor. This causes the recruitment of a BMP type I receptor, which the type II receptor phosphorylates. The type I receptor phosphorylates an R-SMAD, a transcriptional regulator.