BNC-210

BNC-210
Clinical data
ATC code
  • none
Legal status
Legal status
  • Investigational
Identifiers
  • L-Isoleucyl-L-tryptophan
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H23N3O3
Molar mass317.389 g·mol−1
3D model (JSmol)
  • CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)N
  • InChI=1S/C17H23N3O3/c1-3-10(2)15(18)16(21)20-14(17(22)23)8-11-9-19-13-7-5-4-6-12(11)13/h4-7,9-10,14-15,19H,3,8,18H2,1-2H3,(H,20,21)(H,22,23)/t10-,14-,15-/m0/s1
  • Key:BVRPESWOSNFUCJ-LKTVYLICSA-N

BNC210 (also known as IW-2143 during its time licensed to Ironwood Pharmaceuticals) is an anxiolytic drug that acts via negative allosteric modulation of the α7-nicotinic acetylcholine receptor,[1] by Bionomics Limited. It is currently being investigated for the treatment of post traumatic stress disorder.[2] The drug has demonstrated clinically significant anxiety reduction in both animal models and in Phase I trials.[3]

It appears to be devoid of significant sedation or memory-impairing side effects, as well as lacking addictive potential in rat discriminatory models.[4]

Phase I trials have shown no serious side effects.

Bionomics previously licensed it to Ironwood Pharmaceuticals in January 2012, where it was known as IW-2143. In December 2012, IW-2143 begun undergoing phase I clinical trials in the United States,[5] but in November 2014, was released back to Bionomics in a mutual agreement.[6] Bionomics will now continue development and clinical testing, with Ironwood receiving a royalty for their work done.

In April 2015, BNC210 was in phase II clinical trials.[7] The estimated study completion date was September 2018.[2] In October 2018, the company announced that the candidate failed to meet its primary endpoint in treating PTSD but may have shown some anti-depressant and anxiolytic effects (the phase II trial's secondary endpoints). The drug is still being developed[8] and secured Fast Track designation from the FDA based on the drug's novel mechanism of action and the 'large unmet need with PTSD' in the community.[9] There is a large unmet need for efficacious anxiolytics which do not have the habituation, dependency, sedation, tolerance, and intoxication issues with current generation anxiolytics.

  1. ^ "Bionomics Begins Phase 1b Study With Anxiety Drug BNC210" (PDF). Bionomics Limited. 2 February 2015.
  2. ^ a b Clinical trial number NCT02933606 at ClinicalTrials.gov
  3. ^ "Bionomics - Pipeline". Retrieved 2010-11-09. Bionomics has discovered a novel compound, BNC210, that offers dramatic competitive advantages over existing treatments
  4. ^ O'Connor S, Andriambeloson E, Huyard B, Wagner S, Sleebs B, Quasi N, Bui C, Street I. "BNC210: A Novel Compound with Potent Anxiolytic Activity" (PDF). Bionomics Limited. Retrieved 2010-11-09. By applying a targeted medicinal chemistry strategy beginning from a compound cited in the literature, Bionomics has developed BNC210
  5. ^ "Ironwood Pharmaceuticals Provides Fourth Quarter 2012 Investor Update (NASDAQ:IRWD)". Archived from the original on 2014-05-04. Retrieved 2013-02-01.
  6. ^ "Daily news on ASX-listed biotechnology companies" (PDF). Biotech Daily. 11 November 2014.
  7. ^ Bionomics Limited. "Bionomics Initiates Phase II Clinical Trial of BNC210 for Treatment of Anxiety". www.prnewswire.com. PRNewswire. Retrieved 2015-06-10.
  8. ^ Bionomics Limited Press Release (2018-10-03). "Pipeline Review". PRNewswire. Retrieved 2020-09-09.
  9. ^ Bionomics Limited Press Release (2019-11-04). "Bionomics Announces Fast Track Designation Granted by U.S. FDA to BNC210 Development Program for the Treatment of PTSD". BusinessWire. Retrieved 2020-09-09.