BPIFA1

BPIFA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBPIFA1, LUNX, NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5, BPI fold containing family A member 1
External IDsOMIM: 607412; MGI: 1338036; HomoloGene: 7895; GeneCards: BPIFA1; OMA:BPIFA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243193
NM_016583
NM_130852

NM_011126

RefSeq (protein)

NP_001230122
NP_057667
NP_570913

NP_035256

Location (UCSC)Chr 20: 33.24 – 33.24 MbChr 2: 153.98 – 153.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BPI fold containing family A, member 1 (BPIFA1), also known as Palate, lung, and nasal epithelium clone (PLUNC),[5] is a protein that in humans is encoded by the BPIFA1 gene.[6][7] It was also formerly known as "Secretory protein in upper respiratory tracts" (SPURT). The BPIFA1 gene sequence predicts 4 transcripts (splice variants); 3 mRNA variants have been well characterized. The resulting BPIFA1 is a secreted protein, expressed at very high levels in mucosa of the airways (olfactory and respiratory and epithelium) and salivary glands; at high levels in oropharyneal epithelium, including tongue and tonsils; and at moderate levels many other tissue types and glands including pituitary, testis, lung, bladder, blood, prostate, pancreas, levels in the digestive tract (tongue, stomach, intestinal epithelium) and pancreas.[8] The protein can be detected on the apical side of epithelial cells and in airway surface liquid, nasal mucus, and sputum.[9]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198183Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027483Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ghafouri B (2003). "PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid". Biochem Soc Trans. 31 (4): 810–4. doi:10.1042/bst0310810. PMID 12887311.
  6. ^ "BPIFA1 BPI fold containing family A member 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
  7. ^ Bingle CD, Bingle L (Oct 2000). "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (3): 363–7. doi:10.1016/S0167-4781(00)00196-2. PMID 11018263.
  8. ^ "Gene : BPIFA1 - ENSG00000198183". bgee.org. The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals.
  9. ^ "Q9NP55 - BPIA1_HUMAN". www.uniprot.org.