BPIFA2

BPIFA2
Identifiers
Aliases	BPIFA2, C20orf70, PSP, SPLUNC2, bA49G10.1, BPI fold containing family A member 2
External IDs	MGI: 97787; HomoloGene: 69034; GeneCards: BPIFA2; OMA:BPIFA2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	33,181,412 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	153,857,999 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; nasal epithelium; ; tongue; ; body of tongue; ; mucosa of ileum; ; tibialis anterior muscle; ; sperm; ; superior surface of tongue; ; gonad; ; olfactory zone of nasal mucosa;
	Top expressed in
	parotid gland; ; lacrimal gland; ; submandibular gland; ; extraocular muscle; ; masseter muscle; ; sexually immature organism; ; lymph node; ; olfactory epithelium; ; lumbar subsegment of spinal cord; ; meninges;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; lipopolysaccharide binding; lipid binding;
Cellular component	extracellular exosome; extracellular region;
Biological process	defense response to bacterium; antimicrobial humoral response;
	Sources:Amigo / QuickGO
Orthologs
	140683
	19194
	ENSG00000131050
	ENSMUSG00000042459
	Q96DR5
	P07743
	NM_080574; NM_001319164
	NM_008953
	NP_001306093; NP_542141
	NP_032979
	Wikidata
View/Edit Human	View/Edit Mouse

BPI fold containing family A, member 2 (BPIFA2), also known as Parotid Secretory Protein (PSP), is a protein that in humans is encoded by the BPIFA2 gene.^[5] The BPIFA2 gene sequence predicts multiple transcripts (splice variants); 2 mRNA variants have been well characterized. The resulting BPIFA2 is a secreted protein, expressed at very high levels in the parotid (salivary) gland; at high levels in oropharyngeal mucosa, including tongue; and at moderate levels many other tissue types and glands including mammary gland, testis, lung, bladder, blood, prostate, adrenal gland, kidney, and pancreas.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131050 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042459 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "BPIFA2 BPI fold containing family A member 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
^ "Gene : BPIFA2 - ENSG00000131050". bgee.org. The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131050 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042459 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "BPIFA2 BPI fold containing family A member 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.

[6] "Gene : BPIFA2 - ENSG00000131050". bgee.org. The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals.

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