BRD2

BRD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X0J, 2DVQ, 2DVR, 2DVS, 2DVV, 2E3K, 2G4A, 2YDW, 2YEK, 3AQA, 3ONI, 4A9E, 4A9F, 4A9H, 4A9I, 4A9J, 4A9M, 4A9N, 4A9O, 4AKN, 4ALG, 4ALH, 4J1P, 4MR5, 4MR6, 4QEU, 4QEV, 4QEW, 4UYF, 4UYG, 4UYH, 5BT5, 5DFD, 5HEM, 5DFB, 5HEL, 5HFQ, 5HEN, 5DFC, 5IG6, 5IBN, 5DW1
Identifiers
Aliases	BRD2, D6S113E, FSH, FSRG1, NAT, RING3, RNF3, O27.1.1, bromodomain containing 2, BRD2-IT1
External IDs	OMIM: 601540; MGI: 99495; HomoloGene: 74540; GeneCards: BRD2; OMA:BRD2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,981,505 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,341,608 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; granulocyte; ; ganglionic eminence; ; left lobe of thyroid gland; ; right testis; ; right lobe of thyroid gland; ; left testis; ; pituitary gland; ; anterior pituitary; ; cerebellar hemisphere;
	Top expressed in
	tail of embryo; ; genital tubercle; ; Rostral migratory stream; ; lacrimal gland; ; internal carotid artery; ; neural layer of retina; ; ventricular zone; ; yolk sac; ; external carotid artery; ; granulocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding; protein binding; lysine-acetylated histone binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; nuclear speck;
Biological process	regulation of transcription by RNA polymerase II; nucleosome assembly; regulation of transcription, DNA-templated; transcription, DNA-templated; spermatogenesis; chromatin organization; viral process;
	Sources:Amigo / QuickGO
Orthologs
	6046
	14312
ENSG00000215077; ENSG00000234507; ENSG00000230678; ENSG00000204256; ENSG00000235307;
	ENSG00000236227; ENSG00000234704
	ENSMUSG00000024335
	P25440
	Q7JJ13
	NM_001113182; NM_001199455; NM_001199456; NM_001291986; NM_005104
	NM_001025387; NM_001204973; NM_010238
	NP_001106653; NP_001186384; NP_001186385; NP_001278915; NP_005095
	NP_001191902; NP_034368
	Wikidata
View/Edit Human	View/Edit Mouse

Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals ^[5]^[6]^[7]

Early descriptions demonstrated that BRD2 gene product is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.^[7]

^ ^a ^b ^c ENSG00000234507, ENSG00000230678, ENSG00000204256, ENSG00000235307, ENSG00000236227, ENSG00000234704 GRCh38: Ensembl release 89: ENSG00000215077, ENSG00000234507, ENSG00000230678, ENSG00000204256, ENSG00000235307, ENSG00000236227, ENSG00000234704 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024335 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Belkina, A. C.; Denis, G. V. (2012). "BET domain co-regulators in obesity, inflammation and cancer". Nature Reviews Cancer. 12 (7): 465–77. doi:10.1038/nrc3256. PMC 3934568. PMID 22722403.
^ Thorpe KL, Abdulla S, Kaufman J, Trowsdale J, Beck S (October 1996). "Phylogeny and structure of the RING3 gene". Immunogenetics. 44 (5): 391–6. doi:10.1007/BF02602785. PMID 8781126. S2CID 44613743.
^ ^a ^b "BRD2 bromodomain containing 2 [ Homo sapiens (human) ]".

[refGRCh38Ensembl-1] ENSG00000234507, ENSG00000230678, ENSG00000204256, ENSG00000235307, ENSG00000236227, ENSG00000234704 GRCh38: Ensembl release 89: ENSG00000215077, ENSG00000234507, ENSG00000230678, ENSG00000204256, ENSG00000235307, ENSG00000236227, ENSG00000234704 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024335 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid22722403-5] Belkina, A. C.; Denis, G. V. (2012). "BET domain co-regulators in obesity, inflammation and cancer". Nature Reviews Cancer. 12 (7): 465–77. doi:10.1038/nrc3256. PMC 3934568. PMID 22722403.

[pmid8781126-6] Thorpe KL, Abdulla S, Kaufman J, Trowsdale J, Beck S (October 1996). "Phylogeny and structure of the RING3 gene". Immunogenetics. 44 (5): 391–6. doi:10.1007/BF02602785. PMID 8781126. S2CID 44613743.

[entrez-7] "BRD2 bromodomain containing 2 [ Homo sapiens (human) ]".

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