BRD4

BRD4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I8N, 2LSP, 2MJV, 2OSS, 2OUO, 2YEL, 2YEM, 3MXF, 3P5O, 3SVF, 3SVG, 3U5J, 3U5K, 3U5L, 3UVW, 3UVX, 3UVY, 3UW9, 3ZYU, 4A9L, 4BJX, 4BW1, 4BW2, 4BW3, 4BW4, 4C66, 4C67, 4CFK, 4CFL, 4CL9, 4CLB, 4DON, 4E96, 4F3I, 4GPJ, 4HBV, 4HBW, 4HBX, 4HBY, 4HXK, 4HXL, 4HXM, 4HXN, 4HXO, 4HXP, 4HXR, 4HXS, 4IOO, 4IOQ, 4IOR, 4J0R, 4J0S, 4J3I, 4KV1, 4KV4, 4LR6, 4LRG, 4LYI, 4LYS, 4LYW, 4LZR, 4LZS, 4MEN, 4MEO, 4MEP, 4MEQ, 4MR3, 4MR4, 4NQM, 4NR8, 4NUC, 4NUD, 4NUE, 4O70, 4O71, 4O72, 4O74, 4O75, 4O76, 4O77, 4O78, 4O7A, 4O7B, 4O7C, 4O7E, 4O7F, 4OGI, 4OGJ, 4PCE, 4PCI, 4PS5, 4QB3, 4QR3, 4QR4, 4QR5, 4QZS, 4UIX, 4UIZ, 4UYD, 4WIV, 4XY9, 4XYA, 4Z1Q, 4Z1S, 4Z93, 5A5S, 5A85, 5BT4, 5D3T, 5D3S, 5D3H, 5D3J, 5CTL, 4WHW, 5D3R, 4X2I, 5CPE, 5CRZ, 4YH3, 4ZC9, 5EI4, 5D3P, 5CQT, 5D3L, 5EIS, 5CRM, 5D0C, 5EGU, 5CP5, 5D25, 5CY9, 5COI, 5D26, 4YH4, 5CS8, 5ACY, 5DX4, 5D24, 5HM0, 5HLS, 2N3K, 5JWM, 5DLX, 2NCZ, 2NNU, 5DW2, 2ND1, 4ZW1, 5CFW, 2ND0, 5DLZ
Identifiers
Aliases	BRD4, CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4
External IDs	OMIM: 608749; MGI: 1888520; HomoloGene: 137685; GeneCards: BRD4; OMA:BRD4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 15,235,519 bp[1] End 15,332,545 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.39 cM Start 32,196,274 bp[2] End 32,284,722 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell sural nerve tendon of biceps brachii nipple internal globus pallidus pylorus secondary oocyte cardia renal medulla vena cava Top expressed in Rostral migratory stream genital tubercle tail of embryo cumulus cell blood zygote internal carotid artery ascending aorta secondary oocyte aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function p53 binding chromatin binding protein binding lysine-acetylated histone binding RNA polymerase II complex binding RNA polymerase II CTD heptapeptide repeat kinase activity enzyme binding RNA polymerase II C-terminal domain binding P-TEFb complex binding Cellular component nucleoplasm chromosome condensed nuclear chromosome nucleus cytosol Biological process chromatin remodeling regulation of transcription, DNA-templated negative regulation of DNA damage checkpoint regulation of transcription involved in G1/S transition of mitotic cell cycle transcription, DNA-templated cellular response to DNA damage stimulus regulation of inflammatory response positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of G2/M transition of mitotic cell cycle regulation of phosphorylation of RNA polymerase II C-terminal domain viral process positive regulation of transcription elongation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II chromatin organization protein phosphorylation positive regulation of transcription, DNA-templated positive regulation of histone H3-K36 trimethylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23476 57261 Ensembl ENSG00000141867 ENSMUSG00000024002 UniProt O60885 Q9ESU6 RefSeq (mRNA) NM_014299 NM_058243 NM_001330384 NM_001379291 NM_001379292 NM_001286630 NM_020508 NM_198094 RefSeq (protein) NP_001317313 NP_055114 NP_490597 NP_001366220 NP_001366221 NP_001273559 NP_065254 NP_932762 Location (UCSC) Chr 19: 15.24 – 15.33 Mb Chr 17: 32.2 – 32.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene.^[5][6]

BRD4 is a member of the BET (bromodomain and extra terminal domain) family, which also includes BRD2, BRD3, and BRDT.^[7] BRD4, similar to other BET family members, contains two bromodomains that recognize acetylated lysine residues.^[8] BRD4 also has an extended C-terminal domain with little sequence homology to other BET family members.^[7]