BRIP1

BRIP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T15, 1T29, 3AL3
Identifiers
Aliases	BRIP1, BACH1, FANCJ, OF, BRCA1 interacting protein C-terminal helicase 1, BRCA1 interacting helicase 1
External IDs	OMIM: 605882; MGI: 2442836; HomoloGene: 32766; GeneCards: BRIP1; OMA:BRIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	61,863,559 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	86,092,019 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gonad; ; testicle; ; secondary oocyte; ; ganglionic eminence; ; stromal cell of endometrium; ; bone marrow; ; bone marrow cells; ; trabecular bone; ; left testis;
	Top expressed in
	zygote; ; primary oocyte; ; genital tubercle; ; tail of embryo; ; secondary oocyte; ; yolk sac; ; morula; ; gray matter layer of cerebellum; ; ventricular zone; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; 4 iron, 4 sulfur cluster binding; nucleotide binding; helicase activity; iron-sulfur cluster binding; DNA helicase activity; metal ion binding; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; protein binding; nucleic acid binding; hydrolase activity; ATP binding; chromatin binding;
Cellular component	cytoplasm; nuclear membrane; nucleoplasm; nucleus;
Biological process	regulation of transcription by RNA polymerase II; DNA damage checkpoint signaling; cellular response to DNA damage stimulus; cellular response to vitamin; nucleobase-containing compound metabolic process; negative regulation of cell population proliferation; DNA replication; DNA duplex unwinding; double-strand break repair; DNA repair; homologous chromosome pairing at meiosis; spermatogenesis; spermatogonial cell division; spermatid development; male gonad development; response to toxic substance; negative regulation of gene expression; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination; chiasma assembly; cellular response to hypoxia; seminiferous tubule development; cellular response to angiotensin; double-strand break repair involved in meiotic recombination; nucleotide-excision repair; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	83990
	237911
	ENSG00000136492
	ENSMUSG00000034329
	Q9BX63
	Q5SXJ3
	NM_032043
	NM_178309
	NP_114432
	NP_840094
	Wikidata
View/Edit Human	View/Edit Mouse

Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136492 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034329 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Menichini P, Linial M (November 2001). "SUVi and BACH1: a new subfamily of mammalian helicases?". Mutation Research. 487 (1–2): 67–71. doi:10.1016/s0921-8777(01)00104-5. PMID 11595410.
^ Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, et al. (April 2001). "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function". Cell. 105 (1): 149–160. doi:10.1016/S0092-8674(01)00304-X. PMID 11301010. S2CID 15966253.
^ "Entrez Gene: BRIP1 BRCA1 interacting protein C-terminal helicase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136492 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034329 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11595410-5] Menichini P, Linial M (November 2001). "SUVi and BACH1: a new subfamily of mammalian helicases?". Mutation Research. 487 (1–2): 67–71. doi:10.1016/s0921-8777(01)00104-5. PMID 11595410.

[pmid11301010-6] Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, et al. (April 2001). "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function". Cell. 105 (1): 149–160. doi:10.1016/S0092-8674(01)00304-X. PMID 11301010. S2CID 15966253.

[entrez-7] "Entrez Gene: BRIP1 BRCA1 interacting protein C-terminal helicase 1".

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