BUB1B

BUB1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WVI, 3SI5, 4GGD, 5JJA
Identifiers
Aliases	BUB1B, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, BUB1 mitotic checkpoint serine/threonine kinase B
External IDs	OMIM: 602860; MGI: 1333889; HomoloGene: 933; GeneCards: BUB1B; OMA:BUB1B - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	40,221,123 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	118,472,072 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; gonad; ; embryo; ; Epithelium of choroid plexus; ; ganglionic eminence; ; right testis; ; bone marrow; ; left testis; ; trabecular bone;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; ectoderm; ; otic vesicle; ; primitive streak; ; otic placode; ; tail of embryo; ; spermatocyte; ; genital tubercle; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activity; ATP binding; protein binding; kinase activity; nucleotide binding; transferase activity; protein kinase activity;
Cellular component	kinetochore; nucleus; cytoskeleton; outer kinetochore; microtubule organizing center; perinuclear region of cytoplasm; chromosome, centromeric region; anaphase-promoting complex; chromosome; cytoplasm; spindle midzone; cytosol; spindle;
Biological process	protein localization to chromosome, centromeric region; anaphase-promoting complex-dependent catabolic process; mitotic cell cycle checkpoint signaling; protein phosphorylation; metaphase; cell cycle; apoptotic process; phosphorylation; cell division; cell population proliferation; protein localization to kinetochore; mitotic spindle assembly checkpoint signaling; meiotic sister chromatid cohesion, centromeric; mitotic cell cycle; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	701
	12236
	ENSG00000156970
	ENSMUSG00000040084
	O60566
	Q9Z1S0
	NM_001211
	NM_009773
	NP_001202
	NP_033903
	Wikidata
View/Edit Human	View/Edit Mouse

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene.^[5] Also known as BubR1, this protein is recognized for its mitotic roles in the spindle assembly checkpoint (SAC) and kinetochore-microtubule interactions that facilitate chromosome migration and alignment. BubR1 promotes mitotic fidelity and protects against aneuploidy by ensuring proper chromosome segregation between daughter cells. BubR1 is proposed to prevent tumorigenesis.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156970 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040084 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davenport JW, Fernandes ER, Harris LD, Neale GA, Goorha R (January 1999). "The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner". Genomics. 55 (1): 113–117. doi:10.1006/geno.1998.5629. PMID 9889005.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156970 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040084 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9889005-5] Davenport JW, Fernandes ER, Harris LD, Neale GA, Goorha R (January 1999). "The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner". Genomics. 55 (1): 113–117. doi:10.1006/geno.1998.5629. PMID 9889005.

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