Basal-like carcinoma

Histopathology of features often seen in basal-like breast cancer: Low magnification at left shows large geographic necroses (pink homogenous areas), and high magnification at right shows highly pleomorphic nuclei and ample mitoses. H&E stain.

The basal-like carcinoma is a recently proposed subtype of breast cancer defined by its gene expression and protein expression profile.[1]

Breast cancer can be divided into five molecular subtypes, including luminal subtype A, luminal subtype B, normal breast-like subtype, HER-2 overexpression subtype) and basal-like subtype.[2] Genotyping fundamentally provides breast cancer patients with improved prognosis and treatment. In all molecular subtypes, basal-like breast cancer (BLBC) is still the biggest challenge in current research due to its strong invasiveness and molecular biological characteristics.

  1. ^ Livasy CA, Karaca G, Nanda R, Tretiakova MS, Olopade OI, Moore DT, et al. (February 2006). "Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma". Modern Pathology. 19 (2): 264–71. doi:10.1038/modpathol.3800528. PMID 16341146.
  2. ^ Kapp AV, Jeffrey SS, Langerød A, Børresen-Dale AL, Han W, Noh DY, et al. (September 2006). "Discovery and validation of breast cancer subtypes". BMC Genomics. 7 (1): 231. doi:10.1186/1471-2164-7-231. PMC 1574316. PMID 16965636.