Bempedoic acid

Bempedoic acid
Clinical data
Trade namesNexletol, Nilemdo
Other namesESP-55016, ETC-1002
AHFS/Drugs.comMonograph
MedlinePlusa620020
License data
Pregnancy
category
  • Contraindicated
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding99.3%[2]
MetabolismGlucuronidation
Elimination half-life21±11 hrs
Excretion70% urine, 30% feces
Identifiers
  • 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.238.679 Edit this at Wikidata
Chemical and physical data
FormulaC19H36O5
Molar mass344.492 g·mol−1
3D model (JSmol)
  • CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O
  • InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
  • Key:HYHMLYSLQUKXKP-UHFFFAOYSA-N

Bempedoic acid, sold under the brand name Nexletol among others, is a medication for the treatment of hypercholesterolemia (high blood cholesterol levels).[2][3]

The most common side effects include hyperuricemia (high blood levels of uric acid), pain in arms or legs, and anemia (low red blood cell counts).[3]

Bempedoic acid blocks an enzyme in the liver called adenosine triphosphate-citrate lyase, which is involved in making cholesterol.[3]

Bempedoic acid was approved for use in the United States in February 2020, and for use in the European Union in April 2020.[3][5][6] The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[7]

  1. ^ "Nilemdo 180mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 4 September 2020. Retrieved 17 January 2021.
  2. ^ a b c "Nexletol- bempedoic acid tablet, film coated". DailyMed. U.S. National Library of Medicine. 10 March 2020. Retrieved 19 March 2020.
  3. ^ a b c d e "Nilemdo EPAR". European Medicines Agency (EMA). 29 January 2020. Retrieved 24 April 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  4. ^ "Nilemdo Product information". Union Register of medicinal products. Retrieved 3 March 2023.
  5. ^ "Drug Approval Package: Nexletol". U.S. Food and Drug Administration (FDA). 24 March 2020. Retrieved 17 January 2021.
  6. ^ Cite error: The named reference FDA snapshot was invoked but never defined (see the help page).
  7. ^ "New Drug Therapy Approvals 2020". U.S. Food and Drug Administration (FDA). 31 December 2020. Retrieved 17 January 2021.