Berlin Ostkreuz station (German: Bahnhof Berlin Ostkreuz) (literally "Berlin East Cross") is a station on the Berlin S-Bahn suburban railway and the busiest interchange station in Berlin. It is in the former East Berlin district of Friedrichshain, now part of the borough of Friedrichshain-Kreuzberg. A smaller part of the station is in Rummelsburg, part of the borough of Lichtenberg. The station is a Turmbahnhof ("tower station", i.e., a two-level interchange) with the Berlin–Frankfurt (Oder) railway ("Lower Silesian–March Railway") and the Prussian Eastern Railway on the lower level and the Berlin Ringbahn on the upper level. It is used by a total of around 235,000 passengers every day on eight lines, entering or leaving.
The station was completely reconstructed from 2006 to December 2018 while operations continued. In the past it was exclusively used as a Berlin S-Bahn station, but it is now also a stopping point for regional services.