Bernadine is a female given name, a variant spelling of Bernardine. Notable people with the name include:
- Bernadine Bezuidenhout (born 1993), New Zealand cricketer
- Bernadine Craft, American politician from Wyoming
- Bernadine Custer (1900–1991), American artist
- Bernadene Hayes (1912–1987), American actress
- Bernadine Hayes (c. 1912–1987, American singer and actress
- Bernadine Healy (1944–2011), American cardiologist
- Bernadine Jayasinghe, TV personality, winner of a president's award and leading soft skills trainer
- Bernadine Kent, American politician from Ohio
- Bernadine Maxwell (died 1988), American All-American Girls Professional Baseball League player
- Bernadine Newsom Denning (1930–2011), American educator and civil rights activist
- Bernadine Oliver-Kerby (born 1971), New Zealand broadcaster