Beta-1 adrenergic receptor

ADRB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LSQ
Identifiers
Aliases	ADRB1, ADRB1R, B1AR, BETA1AR, RHR, adrenoceptor beta 1, FNSS2
External IDs	OMIM: 109630; MGI: 87937; HomoloGene: 20171; GeneCards: ADRB1; OMA:ADRB1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.3 Start 114,043,866 bp[1] End 114,046,904 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 D2|19 51.96 cM Start 56,710,631 bp[2] End 56,721,545 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle parotid gland bronchial epithelial cell lower lobe of lung endothelial cell placenta Brodmann area 23 apex of heart postcentral gyrus buccal mucosa cell Top expressed in parotid gland pineal gland right lung right lung lobe submandibular gland left lung primary motor cortex prefrontal cortex nucleus accumbens conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-adrenergic receptor activity PDZ domain binding G protein-coupled receptor activity epinephrine binding norepinephrine binding signal transducer activity adrenergic receptor activity protein binding alpha-2A adrenergic receptor binding protein heterodimerization activity beta1-adrenergic receptor activity G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane endosome membrane plasma membrane integral component of plasma membrane early endosome Schaffer collateral - CA1 synapse integral component of postsynaptic density membrane Biological process fear response adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of multicellular organism growth cell-cell signaling positive regulation of cAMP-mediated signaling positive regulation of heart rate by epinephrine-norepinephrine activation of adenylate cyclase activity norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure diet induced thermogenesis adenylate cyclase-activating adrenergic receptor signaling pathway positive regulation of heart contraction positive regulation of GTPase activity positive regulation of the force of heart contraction by epinephrine-norepinephrine heat generation brown fat cell differentiation response to cold temperature homeostasis signal transduction G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway regulation of postsynaptic membrane potential positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 153 11554 Ensembl ENSG00000043591 ENSMUSG00000035283 UniProt P08588 P34971 RefSeq (mRNA) NM_000684 NM_007419 RefSeq (protein) NP_000675 NP_031445 Location (UCSC) Chr 10: 114.04 – 114.05 Mb Chr 19: 56.71 – 56.72 Mb PubMed search [3] [4]
Wikidata
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The beta-1 adrenergic receptor (β₁ adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors.^[5] It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein that is expressed predominantly in cardiac tissue. In addition to cardiac tissue, beta-1 adrenergic receptors are also expressed in the cerebral cortex.