Beta-actin

ACTB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BYH, 3D2U, 3J82, 3LUE
Identifiers
Aliases	ACTB, BRWS1, PS1TP5BP1, Beta-actin, actin, beta, actin beta
External IDs	OMIM: 102630; MGI: 87904; HomoloGene: 110648; GeneCards: ACTB; OMA:ACTB - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.1 Start 5,526,409 bp[1] End 5,563,902 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 81.8 cM Start 142,888,870 bp[2] End 142,892,509 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein urethra postcentral gyrus synovial joint orbitofrontal cortex mucosa of ileum Brodmann area 46 nipple vena cava olfactory bulb Top expressed in human fetus vas deferens lateral septal nucleus Gonadal ridge mandibular prominence migratory enteric neural crest cell maxillary prominence ventromedial nucleus abdominal wall medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleotide binding nitric-oxide synthase binding Tat protein binding structural constituent of cytoskeleton protein binding kinesin binding identical protein binding nucleosomal DNA binding ATP binding Cellular component cytoplasm blood microparticle membrane focal adhesion NuA4 histone acetyltransferase complex plasma membrane nucleoplasm cytoplasmic ribonucleoprotein granule extracellular exosome cytoskeleton dense body cortical cytoskeleton cytosol myelin sheath extracellular space Biological process epigenetic maintenance of chromatin in transcription-competent conformation substantia nigra development Fc-gamma receptor signaling pathway involved in phagocytosis ephrin receptor signaling pathway retina homeostasis vascular endothelial growth factor receptor signaling pathway platelet aggregation cell junction assembly cytoskeleton organization protein deubiquitination membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60 11461 Ensembl ENSG00000075624 ENSMUSG00000029580 UniProt P60709 P60710 RefSeq (mRNA) NM_001101 NM_007393 RefSeq (protein) NP_001092 NP_031419 Location (UCSC) Chr 7: 5.53 – 5.56 Mb Chr 5: 142.89 – 142.89 Mb PubMed search [3] [4]
Wikidata
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Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins^[5][6] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.^[7]