Blow up, Blow-up or Blowup may refer to:
- Explosion
- Total body disruption, a cause of death typically associated with explosion
- An inflatable
- Blowing up, a mathematical operation
- Blowup, a 1966 film by Michelangelo Antonioni
- Blow-up and Other Stories, a short story collection by Julio Cortázar
- Blow Up (magazine), an Italy-based music magazine
- Blow Up (Dutch TV series)
- Blow Up (Australian TV series), Australian adaptation of the Dutch television series
- Blow Up (French TV series)