Bob or Bobby James may refer to:
- Bob James (sailor) (1933–2016), American sailor
- Bob James (musician) (born 1939), American jazz keyboardist, arranger and producer
- Bob James (baseball) (born 1958), former baseball player for the Expos, Tigers, and White Sox
- Bob James (rock singer) (1952–2021), American singer, frontman of Montrose, 1974–76
- Bob James (country singer) (born 1960), English singer, former representative of CMT Europe, 1995–97
- Bob James, saxophonist and guitar player for British progressive rock band Skin Alley
- Bobby James (American football), American football coach
- Bobby James, a song from the 2001 N.E.R.D. album In Search of...