Bone marrow adipose tissue

Bone marrow adipose tissue
Details
SystemMusculoskeletal (or locomotor)
Identifiers
Latinadipose ossium medulla
Anatomical terminology
Bone marrow adipocytes are derived from mesenchymal stem cell (MSC) differentiation.

Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone marrow. It increases in states of low bone density, such as osteoporosis,[1][2] anorexia nervosa/caloric restriction,[3][4] skeletal unweighting such as that which occurs in space travel,[5][6] and anti-diabetes therapies.[7] BMAT decreases in anaemia, leukaemia, and hypertensive heart failure; in response to hormones such as oestrogen, leptin, and growth hormone; with exercise-induced weight loss or bariatric surgery; in response to chronic cold exposure; and in response to pharmacological agents such as bisphosphonates, teriparatide, and metformin.[8]

  1. ^ Cohen A, Dempster DW, Stein EM, Nickolas TL, Zhou H, McMahon DJ, et al. (August 2012). "Increased marrow adiposity in premenopausal women with idiopathic osteoporosis". The Journal of Clinical Endocrinology and Metabolism. 97 (8): 2782–2791. doi:10.1210/jc.2012-1477. PMC 3410269. PMID 22701013.
  2. ^ Meunier P, Aaron J, Edouard C, Vignon G (October 1971). "Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies". Clinical Orthopaedics and Related Research. 80: 147–154. doi:10.1097/00003086-197110000-00021. PMID 5133320.
  3. ^ Fazeli PK, Horowitz MC, MacDougald OA, Scheller EL, Rodeheffer MS, Rosen CJ, Klibanski A (March 2013). "Marrow fat and bone--new perspectives". The Journal of Clinical Endocrinology and Metabolism. 98 (3): 935–945. doi:10.1210/jc.2012-3634. PMC 3590487. PMID 23393168.
  4. ^ McGrath C, Sankaran JS, Misaghian-Xanthos N, Sen B, Xie Z, Styner MA, et al. (January 2020). "Exercise Degrades Bone in Caloric Restriction, Despite Suppression of Marrow Adipose Tissue (MAT)". Journal of Bone and Mineral Research. 35 (1): 106–115. doi:10.1002/jbmr.3872. PMC 6980282. PMID 31509274.
  5. ^ Ahdjoudj S, Lasmoles F, Holy X, Zerath E, Marie PJ (April 2002). "Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma". Journal of Bone and Mineral Research. 17 (4): 668–677. doi:10.1359/jbmr.2002.17.4.668. PMID 11918224. S2CID 23060094.
  6. ^ Wronski TJ, Morey ER (1982-01-01). "Skeletal abnormalities in rats induced by simulated weightlessness". Metabolic Bone Disease & Related Research. 4 (1): 69–75. doi:10.1016/0221-8747(82)90011-X. PMID 7121257.
  7. ^ Rubin MR, Manavalan JS, Agarwal S, McMahon DJ, Nino A, Fitzpatrick LA, Bilezikian JP (October 2014). "Effects of rosiglitazone vs metformin on circulating osteoclast and osteogenic precursor cells in postmenopausal women with type 2 diabetes mellitus". The Journal of Clinical Endocrinology and Metabolism. 99 (10): E1933–E1942. doi:10.1210/jc.2013-3666. PMID 24905061.
  8. ^ Cawthorn W (2020). "Bone Marrow Adipose Tissue". Encyclopedia of Bone Biology. Oxford, UK: Academic Press. pp. 156–177. doi:10.1016/B978-0-12-801238-3.11207-3. ISBN 978-0-12-814082-6. S2CID 213762507.