Bone morphogenetic protein 5

BMP5
Identifiers
Aliases	BMP5, entrez:653, bone morphogenetic protein 5
External IDs	OMIM: 112265; MGI: 88181; HomoloGene: 22412; GeneCards: BMP5; OMA:BMP5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.1 Start 55,753,653 bp[1] End 55,875,590 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 42.34 cM Start 75,682,646 bp[2] End 75,807,592 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon islet of Langerhans cartilage tissue tibia placenta Epithelium of choroid plexus mucosa of urinary bladder rectum jejunal mucosa right lung Top expressed in secondary oocyte zygote primary oocyte vestibular sensory epithelium left lung lobe vestibular membrane of cochlear duct Paneth cell skin of external ear carotid body right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity BMP receptor binding transforming growth factor beta receptor binding growth factor activity Cellular component extracellular region extracellular space vesicle cellular component Biological process regulation of apoptotic process pattern specification process skeletal system development cell differentiation male genitalia development regulation of MAPK cascade SMAD protein signal transduction ossification positive regulation of epithelial cell proliferation negative regulation of mononuclear cell migration negative regulation of cortisol biosynthetic process positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of dendrite development BMP signaling pathway multicellular organism development cartilage development negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of insulin-like growth factor receptor signaling pathway type B pancreatic cell development negative regulation of steroid biosynthetic process negative regulation of epithelial to mesenchymal transition positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation negative regulation of aldosterone biosynthetic process endocardial cushion formation pericardium morphogenesis neural fold elevation formation hindbrain development cardiac muscle tissue development pharyngeal system development cardiac septum morphogenesis chorio-allantoic fusion heart trabecula morphogenesis allantois development regulation of signaling receptor activity ear development anterior head development positive regulation of cell population proliferation cell development signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 653 12160 Ensembl ENSG00000112175 ENSMUSG00000032179 UniProt P22003 P49003 RefSeq (mRNA) NM_021073 NM_001329754 NM_001329756 NM_007555 RefSeq (protein) NP_001316683 NP_001316685 NP_066551 NP_066551.1 NP_031581 Location (UCSC) Chr 6: 55.75 – 55.88 Mb Chr 9: 75.68 – 75.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.^[5][6][7]

The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.^[7]