Bradykinin receptor B1

BDKRB1
Identifiers
Aliases	BDKRB1, B1BKR, B1R, BDKRB2, BKB1R, BKR1, BRADYB1, Bradykinin receptor B1
External IDs	OMIM: 600337; MGI: 88144; HomoloGene: 570; GeneCards: BDKRB1; OMA:BDKRB1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.2 Start 96,256,210 bp[1] End 96,268,967 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 105,569,344 bp[2] End 105,571,687 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle gallbladder stromal cell of endometrium mucosa of transverse colon ectocervix canal of the cervix vagina body of pancreas appendix Top expressed in choroid plexus of fourth ventricle entorhinal cortex embryo morula zygote secondary oocyte morula embryo primary oocyte lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity peptide binding signal transducer activity protein binding bradykinin receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane endoplasmic reticulum neuron projection Biological process negative regulation of protein phosphorylation negative regulation of blood pressure positive regulation of leukocyte migration positive regulation of cytosolic calcium ion concentration response to stress response to mechanical stimulus positive regulation of release of sequestered calcium ion into cytosol response to lipopolysaccharide protein kinase C-activating G protein-coupled receptor signaling pathway negative regulation of cell growth sensory perception of pain inflammatory response cell migration signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 623 12061 Ensembl ENSG00000100739 ENSMUSG00000041347 UniProt P46663 Q61125 RefSeq (mRNA) NM_000710 NM_001386007 NM_007539 RefSeq (protein) NP_000701 NP_031565 Location (UCSC) Chr 14: 96.26 – 96.27 Mb Chr 12: 105.57 – 105.57 Mb PubMed search [3] [4]
Wikidata
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Bradykinin receptor B1 (B₁) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B₁ receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

B₁ protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.^[5]

Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.^[6]