Brain-specific angiogenesis inhibitor 3

ADGRB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DLO
Identifiers
Aliases	ADGRB3, BAI3, adhesion G protein-coupled receptor B3
External IDs	OMIM: 602684; MGI: 2441837; HomoloGene: 1289; GeneCards: ADGRB3; OMA:ADGRB3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	69,390,571 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	25,868,788 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; endothelial cell; ; Brodmann area 23; ; ventricular zone; ; orbitofrontal cortex; ; superior frontal gyrus; ; Brodmann area 46; ; postcentral gyrus; ; entorhinal cortex; ; Region I of hippocampus proper;
	Top expressed in
	lateral septal nucleus; ; nucleus accumbens; ; anterior amygdaloid area; ; olfactory tubercle; ; ventromedial nucleus; ; lobe of cerebellum; ; cerebellar vermis; ; medial geniculate nucleus; ; subiculum; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; transmembrane signaling receptor activity; signal transducer activity; GTPase activator activity;
Cellular component	integral component of membrane; plasma membrane; membrane; postsynapse; synaptic cleft; intracellular anatomical structure; integral component of plasma membrane;
Biological process	negative regulation of angiogenesis; G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; cell surface receptor signaling pathway; myoblast fusion; signal transduction; positive regulation of synapse assembly; regulation of dendrite morphogenesis; motor learning; maintenance of synapse structure; neuron remodeling; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	577
	210933
	ENSG00000135298
	ENSMUSG00000033569
	O60242
	Q80ZF8
	NM_001704
	NM_175642
	NP_001695
	NP_783573
	Wikidata
View/Edit Human	View/Edit Mouse

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.^[5]^[6]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.^[6] The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.^[7]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.^[8] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135298 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033569 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics. 79 (1–2): 103–108. doi:10.1159/000134693. PMID 9533023.
^ ^a ^b "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".
^ Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, et al. (August 2013). "The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons". Molecular Psychiatry. 18 (8): 943–950. doi:10.1038/mp.2013.46. PMC 3730300. PMID 23628982.
^ Bolliger MF, Martinelli DC, Südhof TC (February 2011). "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 108 (6): 2534–2539. Bibcode:2011PNAS..108.2534B. doi:10.1073/pnas.1019577108. PMC 3038708. PMID 21262840.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135298 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033569 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9533023-5] Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics. 79 (1–2): 103–108. doi:10.1159/000134693. PMID 9533023.

[entrez-6] "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".

[7] Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, et al. (August 2013). "The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons". Molecular Psychiatry. 18 (8): 943–950. doi:10.1038/mp.2013.46. PMC 3730300. PMID 23628982.

[8] Bolliger MF, Martinelli DC, Südhof TC (February 2011). "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 108 (6): 2534–2539. Bibcode:2011PNAS..108.2534B. doi:10.1073/pnas.1019577108. PMC 3038708. PMID 21262840.

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