Brian Clark may refer to:
- Brian Clark (writer) (1932–2021), English playwright and screenwriter
- Brian Clark (footballer, born 1943) (1943–2010), English footballer
- Brian Clark (Scottish footballer) (born 1988), Scottish footballer
- Brian D. Clark (born 1956), Pennsylvania politician
- Brian Clark (American football) (born 1983), American football wide receiver
- Brian Clark (Canadian football) (born 1974), former Canadian Football League linebacker
- Brian Clark (September 11 survivor) (born 1947), Canadian survivor of the attacks on the World Trade Center on September 11, 2001
- Brian Clark (cricketer) (born 1964), Zimbabwean cricketer
- Brian Clark (rugby league), New Zealand rugby league player
- Brian Clark (speedway rider), English motorcycle speedway rider