Brigitta Stockinger

Gitta Stockinger
Born
Brigitta Stockinger
Alma materUniversity of Mainz (PhD)
Awards
Scientific career
Fields
Institutions
Websitenimr.mrc.ac.uk/research/gitta-stockinger

Brigitta Stockinger, FMedSci, FRS, is a molecular immunologist in the Francis Crick Institute in London. Stockinger's lab focus on understanding how certain immune cells, called T cells, develop and function as well as investigating how diet and other environmental factors can affect the way the immune system works.[1]

Stockinger focuses on a particular type of immune cell that helps to control immune responses to viruses, bacteria and other pathogens, called a CD4 T cell.

Stockinger's research has provided insights into a particular type of CD4 T cell, called a Th17 cell, looking at why some of these cells become inflammatory and cause damage in the body. Her lab identified a particular receptor, the aryl hydrocarbon receptor (AhR), which connects environmental stimuli and the immune system.[2][3][4][5][6][7][8][9][10][11]

  1. ^ "Gitta Stockinger". Crick. Retrieved 16 September 2020.
  2. ^ Veldhoen, M.; Hirota, K.; Westendorf, A. M.; Buer, J.; Dumoutier, L.; Renauld, J. C.; Stockinger, B. (2008). "The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins". Nature. 453 (7191): 106–109. Bibcode:2008Natur.453..106V. doi:10.1038/nature06881. hdl:10033/30394. PMID 18362914. S2CID 205212907.
  3. ^ Veldhoen, M.; Uyttenhove, C.; Van Snick, J.; Helmby, H.; Westendorf, A.; Buer, J.; Martin, B.; Wilhelm, C.; Stockinger, B. (2008). "Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset". Nature Immunology. 9 (12): 1341–1346. doi:10.1038/ni.1659. PMID 18931678. S2CID 205361860.
  4. ^ Veldhoen, M; Hocking, R. J.; Atkins, C. J.; Locksley, R. M.; Stockinger, B (2006). "TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells". Immunity. 24 (2): 179–89. doi:10.1016/j.immuni.2006.01.001. PMID 16473830.
  5. ^ Stockinger, B. (2013). "Open questions: A few that need answers in immunology". BMC Biology. 11: 115. doi:10.1186/1741-7007-11-115. PMC 3842812. PMID 24279517.
  6. ^ Brigitta Stockinger publications indexed by Microsoft Academic
  7. ^ Brigitta Stockinger's publications indexed by the Scopus bibliographic database. (subscription required)
  8. ^ Vieira, P. L.; Christensen, J. R.; Minaee, S; O'Neill, E. J.; Barrat, F. J.; Boonstra, A; Barthlott, T; Stockinger, B; Wraith, D. C.; O'Garra, A (2004). "IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells". Journal of Immunology. 172 (10): 5986–93. doi:10.4049/jimmunol.172.10.5986. PMID 15128781.
  9. ^ Stockinger, B.; Veldhoen, M. (2007). "Differentiation and function of Th17 T cells". Current Opinion in Immunology. 19 (3): 281–6. doi:10.1016/j.coi.2007.04.005. PMID 17433650.
  10. ^ Buckley, C. D.; Gilroy, D. W.; Serhan, C. N.; Stockinger, B.; Tak, P. P. (2012). "The resolution of inflammation". Nature Reviews Immunology. 13 (1): 59–66. doi:10.1038/nri3362. PMID 23197111. S2CID 7549769.
  11. ^ Stockinger, B; Zal, T; Zal, A; Gray, D (1996). "B cells solicit their own help from T cells". The Journal of Experimental Medicine. 183 (3): 891–9. doi:10.1084/jem.183.3.891. PMC 2192359. PMID 8642293.