Broadly neutralizing HIV-1 antibodies

Broadly neutralizing HIV-1 antibodies (bNAbs) are neutralizing antibodies which neutralize multiple HIV-1 viral strains.[1] bNAbs are unique in that they target conserved epitopes of the virus, meaning the virus may mutate, but the targeted epitopes will still exist.[2] In contrast, non-bNAbs are specific for individual viral strains with unique epitopes. The discovery of bNAbs has led to an important area of research, namely, discovery of a vaccine, not only limited to HIV, but also other rapidly mutating viruses like influenza.[citation needed]

  1. ^ Eroshkin, AM; LeBlanc, A; Weekes, D; et al. (January 2014). "bNAber: database of broadly neutralizing HIV antibodies". Nucleic Acids Res. 42 (Database issue): D1133–9. doi:10.1093/nar/gkt1083. PMC 3964981. PMID 24214957..
  2. ^ Scheid, J. F.; Mouquet, H.; Feldhahn, N.; Seaman, M. S.; Velinzon, K.; Pietzsch, J.; Nussenzweig, M. C. (2009). "Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals". Nature. 458 (7238): 636–40. Bibcode:2009Natur.458..636S. doi:10.1038/nature07930. PMID 19287373. S2CID 4399760.