Bromazepam

Bromazepam
Clinical data
Trade namesLexotan, Lexotanil, others
AHFS/Drugs.comMicromedex Detailed Consumer Information
Addiction
liability
High[1]
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability84%
Protein binding70%
MetabolismLiver: P450
Metabolites3-hydroxybromazepam
Elimination half-life12–20 hours (avg. 17hr)[3]
ExcretionUrine 69%, as metabolites[1]
Identifiers
  • 7-bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.015.748 Edit this at Wikidata
Chemical and physical data
FormulaC14H10BrN3O
Molar mass316.158 g·mol−1
3D model (JSmol)
  • C1C(=O)NC2=C(C=C(C=C2)Br)C(=N1)C3=CC=CC=N3
  • InChI=1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19) checkY
  • Key:VMIYHDSEFNYJSL-UHFFFAOYSA-N checkY
  (verify)

Bromazepam, sold under many brand names, is a benzodiazepine. It is mainly an anti-anxiety agent with similar side effects to diazepam. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam typically comes in doses of 3 mg and 6 mg tablets.[4]

It was patented in 1961 by Roche and approved for medical use in 1974.[5]

  1. ^ a b "Bromazepam: Uses, Interactions, Mechanism of Action". DrugBank Online. Retrieved 2024-02-25.
  2. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  3. ^ "Lexotan (bromazepam) Product Insert" (PDF). Roche. 23 October 2012.
  4. ^ "Bromazepam". Pharmaceutical Benefits Scheme (PBS). Australian Government - Department of Health. Retrieved 23 March 2014.
  5. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 53X. ISBN 9783527607495.