Bromhexine

Bromhexine
Clinical data
Trade namesBisolvon, others
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability75–80%
MetabolismExtensive hepatic
MetabolitesAmbroxol, others
Elimination half-life12 hr
ExcretionUrine
Identifiers
  • 2,4-Dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.020.622 Edit this at Wikidata
Chemical and physical data
FormulaC14H20Br2N2
Molar mass376.136 g·mol−1
3D model (JSmol)
  • Brc1cc(c(N)c(Br)c1)CN(C)C2CCCCC2
  • InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3 checkY
  • Key:OJGDCBLYJGHCIH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Bromhexine is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus.[1] It was developed in the research laboratory of Boehringer Ingelheim in the late 1950s as an active ingredient for pharmaceutical use, patented in 1961, introduced in 1963 under the trademark of Bisolvon® and came into medical use in 1966.[2]

  1. ^ Morton I, Hall J (1999). Concise Dictionary of Pharmacological Agents. Springer. p. 55. ISBN 0-7514-0499-3. Retrieved 2009-06-03.
  2. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 544. ISBN 9783527607495.