C5AR2

C5AR2
Identifiers
Aliases	C5AR2, C5L2, GPR77, complement component 5a receptor 2, complement C5a receptor 2, C5a2
External IDs	OMIM: 609949; MGI: 2442013; HomoloGene: 49549; GeneCards: C5AR2; OMA:C5AR2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,347,329 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	15,978,079 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; spleen; ; right lung; ; testicle; ; upper lobe of left lung; ; gastric mucosa; ; bone marrow cells; ; left uterine tube;
	Top expressed in
	granulocyte; ; yolk sac; ; placenta; ; secondary oocyte; ; liver; ; bone marrow; ; primary oocyte; ; jejunum; ; esophagus; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; complement component C5a receptor activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; plasma membrane; basal plasma membrane; apical part of cell; membrane; integral component of plasma membrane;
Biological process	negative regulation of neutrophil chemotaxis; chemotaxis; G protein-coupled receptor signaling pathway; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of ERK1 and ERK2 cascade; positive regulation of epithelial cell proliferation; regulation of complement activation; inflammatory response; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; complement component C5a signaling pathway; complement receptor mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	27202
	319430
	ENSG00000134830
	ENSMUSG00000074361
	Q9P296
	Q8BW93
	NM_001271749; NM_001271750; NM_018485
	NM_001146005; NM_176912
	NP_001258678; NP_001258679; NP_060955
	NP_001139477; NP_795886
	Wikidata
View/Edit Human	View/Edit Mouse

Complement component 5a receptor 2 is a protein of the complement system that in humans is encoded by the C5AR2 gene.^[5]^[6] It is highly expressed in the blood and spleen,^[7] predominantly by myeloid cells.^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134830 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074361 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohno M, Hirata T, Enomoto M, Araki T, Ishimaru H, Takahashi TA (June 2000). "A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells". Molecular Immunology. 37 (8): 407–412. doi:10.1016/S0161-5890(00)00067-5. PMID 11090875.
^ "HGNC:4527". Retrieved 2019-08-30.
^ Zhu Y, Wang X, Xu Y, Chen L, Ding P, Chen J, et al. (2021-09-14). "An Integrated Analysis of C5AR2 Related to Malignant Properties and Immune Infiltration of Breast Cancer". Frontiers in Oncology. 11: 736725. doi:10.3389/fonc.2021.736725. PMC 8476960. PMID 34595119.
^ Bamberg CE, Mackay CR, Lee H, Zahra D, Jackson J, Lim YS, et al. (March 2010). "The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction". The Journal of Biological Chemistry. 285 (10): 7633–7644. doi:10.1074/jbc.M109.092106. PMC 2844210. PMID 20044484.
^ Karsten CM, Wiese AV, Mey F, Figge J, Woodruff TM, Reuter T, et al. (November 2017). "Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse". Journal of Immunology. 199 (9): 3234–3248. doi:10.4049/jimmunol.1700710. PMID 28864475.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134830 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074361 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11165367-5] Ohno M, Hirata T, Enomoto M, Araki T, Ishimaru H, Takahashi TA (June 2000). "A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells". Molecular Immunology. 37 (8): 407–412. doi:10.1016/S0161-5890(00)00067-5. PMID 11090875.

[HGNC_GPR77-6] "HGNC:4527". Retrieved 2019-08-30.

[7] Zhu Y, Wang X, Xu Y, Chen L, Ding P, Chen J, et al. (2021-09-14). "An Integrated Analysis of C5AR2 Related to Malignant Properties and Immune Infiltration of Breast Cancer". Frontiers in Oncology. 11: 736725. doi:10.3389/fonc.2021.736725. PMC 8476960. PMID 34595119.

[8] Bamberg CE, Mackay CR, Lee H, Zahra D, Jackson J, Lim YS, et al. (March 2010). "The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction". The Journal of Biological Chemistry. 285 (10): 7633–7644. doi:10.1074/jbc.M109.092106. PMC 2844210. PMID 20044484.

[9] Karsten CM, Wiese AV, Mey F, Figge J, Woodruff TM, Reuter T, et al. (November 2017). "Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse". Journal of Immunology. 199 (9): 3234–3248. doi:10.4049/jimmunol.1700710. PMID 28864475.

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