C5a receptor

C5AR1
Identifiers
Aliases	C5AR1, C5A, C5AR, C5R1, CD88, complement component 5a receptor 1, C5a receptor, complement C5a receptor 1
External IDs	OMIM: 113995; MGI: 88232; HomoloGene: 20413; GeneCards: C5AR1; OMA:C5AR1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,322,066 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	15,993,465 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; bone marrow; ; granulocyte; ; bone marrow cells; ; pituitary gland; ; right lung; ; anterior pituitary; ; periodontal fiber; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; aortic valve; ; stroma of bone marrow; ; ascending aorta; ; blood; ; tibiofemoral joint; ; lumbar spinal ganglion; ; ankle; ; choroid plexus of fourth ventricle; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	complement component C5a binding; signal transducer activity; complement receptor activity; complement component C5a receptor activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; apical part of cell; integral component of plasma membrane; cell surface; basolateral plasma membrane; cytoplasmic vesicle; secretory granule membrane;
Biological process	negative regulation of neuron apoptotic process; positive regulation of epithelial cell proliferation; mRNA transcription by RNA polymerase II; activation of phospholipase C activity; neutrophil chemotaxis; positive regulation of angiogenesis; chemotaxis; cellular defense response; response to lipopolysaccharide; animal organ regeneration; immune response; response to peptidoglycan; positive regulation of ERK1 and ERK2 cascade; positive regulation of neutrophil chemotaxis; complement receptor mediated signaling pathway; sensory perception of chemical stimulus; positive regulation of vascular endothelial growth factor production; cell proliferation in hindbrain; positive regulation of macrophage chemotaxis; signal transduction; defense response to Gram-positive bacterium; apoptotic process; regulation of complement activation; inflammatory response; phospholipase C-activating G protein-coupled receptor signaling pathway; neutrophil degranulation; leukocyte migration; cell chemotaxis; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; complement component C5a signaling pathway; cognition; regulation of astrocyte activation; presynapse organization; regulation of amyloid-beta clearance; regulation of tau-protein kinase activity; regulation of microglial cell activation;
	Sources:Amigo / QuickGO
Orthologs
	728
	12273
	ENSG00000197405
	ENSMUSG00000049130
	P21730
	P30993
	NM_001736
	NM_001173550; NM_007577
	NP_001727
	NP_001167021; NP_031603
	Wikidata
View/Edit Human	View/Edit Mouse

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor.^[5] C5a receptor 1 modulates inflammatory responses, obesity, development and cancers.^[6]^[7]^[8] From a signaling transduction perspective, C5a receptor 1 activation is implicated in β-arrestin2 recruitment via Rab5a,^[9] coupling of Gαi proteins,^[10] ERK1/2 phosphorylation, ^[11] calcium mobilization and Rho activation^[12] leading to downstream functions, such as secretion of cytokines, chemotaxis, and phagocytosis.

C5a receptor structure and its residues possessing role in ligand binding or signaling.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049130 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology. 12: 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
^ Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor SM, Franklin RJ, et al. (April 2015). "The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury". The Journal of Neuroscience. 35 (16): 6517–6531. doi:10.1523/JNEUROSCI.5218-14.2015. PMC 6605214. PMID 25904802.
^ Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, et al. (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–831. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.
^ Markiewski MM, DeAngelis RA, Benencia F, Ricklin-Lichtsteiner SK, Koutoulaki A, Gerard C, et al. (November 2008). "Modulation of the antitumor immune response by complement". Nature Immunology. 9 (11): 1225–1235. doi:10.1038/ni.1655. PMC 2678913. PMID 18820683.
^ Wu KC, Condon ND, Hill TA, Reid RC, Fairlie D, Lim J (March 2023). "Ras related protein Rab5a regulates complement C5a receptor trafficking, chemotaxis and chemokine secretion in human macrophages". Journal of Innate Immunity. 15 (1): 468–484. doi:10.1159/000530012. PMC 10105068. PMID 36882040.
^ Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, et al. (April 2023). "Mechanism of activation and biased signaling in complement receptor C5aR1". Cell Research. 33 (4): 312–324. doi:10.1038/s41422-023-00779-2. PMC 9937529. PMID 36806352.
^ Li XX, Lee JD, Massey NL, Guan C, Robertson AA, Clark RJ, et al. (October 2020). "Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function". Biochemical Pharmacology. 180: 114156. doi:10.1016/j.bcp.2020.114156. PMID 32682759. S2CID 220653568.
^ Wang X, Iyer A, Lyons AB, Körner H, Wei W (2019). "Emerging Roles for G-protein Coupled Receptors in Development and Activation of Macrophages". Frontiers in Immunology. 10: 2031. doi:10.3389/fimmu.2019.02031. PMC 6718513. PMID 31507616.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197405 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049130 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8011297-5] Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology. 12: 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.

[6] Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor SM, Franklin RJ, et al. (April 2015). "The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury". The Journal of Neuroscience. 35 (16): 6517–6531. doi:10.1523/JNEUROSCI.5218-14.2015. PMC 6605214. PMID 25904802.

[7] Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, et al. (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–831. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.

[8] Markiewski MM, DeAngelis RA, Benencia F, Ricklin-Lichtsteiner SK, Koutoulaki A, Gerard C, et al. (November 2008). "Modulation of the antitumor immune response by complement". Nature Immunology. 9 (11): 1225–1235. doi:10.1038/ni.1655. PMC 2678913. PMID 18820683.

[9] Wu KC, Condon ND, Hill TA, Reid RC, Fairlie D, Lim J (March 2023). "Ras related protein Rab5a regulates complement C5a receptor trafficking, chemotaxis and chemokine secretion in human macrophages". Journal of Innate Immunity. 15 (1): 468–484. doi:10.1159/000530012. PMC 10105068. PMID 36882040.

[10] Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, et al. (April 2023). "Mechanism of activation and biased signaling in complement receptor C5aR1". Cell Research. 33 (4): 312–324. doi:10.1038/s41422-023-00779-2. PMC 9937529. PMID 36806352.

[11] Li XX, Lee JD, Massey NL, Guan C, Robertson AA, Clark RJ, et al. (October 2020). "Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function". Biochemical Pharmacology. 180: 114156. doi:10.1016/j.bcp.2020.114156. PMID 32682759. S2CID 220653568.

[12] Wang X, Iyer A, Lyons AB, Körner H, Wei W (2019). "Emerging Roles for G-protein Coupled Receptors in Development and Activation of Macrophages". Frontiers in Immunology. 10: 2031. doi:10.3389/fimmu.2019.02031. PMC 6718513. PMID 31507616.

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