CA1 (gene)

CA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AZM, 1BZM, 1CRM, 1CZM, 1HCB, 1HUG, 1HUH, 1J9W, 1JV0, 2CAB, 2FOY, 2FW4, 2IT4, 2NMX, 2NN1, 2NN7, 3LXE, 3W6H, 3W6I, 4WR7, 4WUP, 4WUQ
Identifiers
Aliases	CA1, CA-I, CAB, Car1, HEL-S-11, carbonic anhydrase 1
External IDs	OMIM: 114800; MGI: 88268; HomoloGene: 20414; GeneCards: CA1; OMA:CA1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	85,379,014 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	14,873,428 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; trabecular bone; ; mucosa of sigmoid colon; ; rectum; ; bone marrow cells; ; monocyte; ; epithelium of colon; ; mucosa of ileum; ; blood; ; testicle;
	Top expressed in
	left colon; ; tibiofemoral joint; ; spleen; ; fetal liver hematopoietic progenitor cell; ; femur; ; body of femur; ; bone marrow; ; granulocyte; ; embryo; ; left lobe of liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; zinc ion binding; lyase activity; hydro-lyase activity; arylesterase activity; protein binding; carbonate dehydratase activity; carbonic anhydrase;
Cellular component	extracellular exosome; cytosol; cytoplasm;
Biological process	one-carbon metabolic process; bicarbonate transport; interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	759
	12346
	ENSG00000133742
	ENSMUSG00000027556
	P00915
	P13634
NM_001128829; NM_001128830; NM_001128831; NM_001164830; NM_001291967;
	NM_001291968; NM_001738
	NM_001083957; NM_009799
NP_001122301; NP_001122302; NP_001122303; NP_001158302; NP_001278896;
	NP_001278897; NP_001729
	NP_001077426; NP_033929
	Wikidata
View/Edit Human	View/Edit Mouse

Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene.^[5]^[6]

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including cellular respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.

They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133742 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027556 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lowe N, Edwards YH, Edwards M, Butterworth PH (Aug 1991). "Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8". Genomics. 10 (4): 882–8. doi:10.1016/0888-7543(91)90176-F. PMID 1916821.
^ ^a ^b "Entrez Gene: CA1 carbonic anhydrase I".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133742 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027556 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1916821-5] Lowe N, Edwards YH, Edwards M, Butterworth PH (Aug 1991). "Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8". Genomics. 10 (4): 882–8. doi:10.1016/0888-7543(91)90176-F. PMID 1916821.

[entrez-6] "Entrez Gene: CA1 carbonic anhydrase I".

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