CACNA1G

CACNA1G
Identifiers
Aliases	CACNA1G, Ca(V)T.1, Cav3.1, NBR13, SCA42, calcium voltage-gated channel subunit alpha1 G, SCA42ND
External IDs	OMIM: 604065; MGI: 1201678; HomoloGene: 22544; GeneCards: CACNA1G; OMA:CACNA1G - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,627,474 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,365,024 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; right hemisphere of cerebellum; ; right frontal lobe; ; primary visual cortex; ; cerebellar vermis; ; endothelial cell; ; prefrontal cortex; ; orbitofrontal cortex; ; dorsolateral prefrontal cortex; ; testicle;
	Top expressed in
	cerebellar cortex; ; medial dorsal nucleus; ; superior frontal gyrus; ; lobe of cerebellum; ; neural layer of retina; ; cerebellar vermis; ; medial geniculate nucleus; ; primary visual cortex; ; lumbar subsegment of spinal cord; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated calcium channel activity; calcium channel activity; scaffold protein binding; voltage-gated ion channel activity; ion channel activity; voltage-gated calcium channel activity involved in AV node cell action potential; voltage-gated calcium channel activity involved SA node cell action potential; low voltage-gated calcium channel activity; voltage-gated sodium channel activity;
Cellular component	integral component of membrane; membrane; voltage-gated calcium channel complex; cytoplasm; plasma membrane;
Biological process	membrane depolarization during action potential; calcium ion import; regulation of membrane potential; regulation of ion transmembrane transport; regulation of atrial cardiac muscle cell membrane depolarization; ion transport; regulation of heart rate; positive regulation of calcium ion-dependent exocytosis; transmembrane transport; action potential; response to nickel cation; calcium ion transport; chemical synaptic transmission; AV node cell to bundle of His cell signaling; regulation of heart rate by cardiac conduction; SA node cell action potential; AV node cell action potential; SA node cell to atrial cardiac muscle cell signaling; membrane depolarization during AV node cell action potential; calcium ion transmembrane transport; membrane depolarization during SA node cell action potential; cardiac muscle cell action potential involved in contraction; neuronal action potential; sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	8913
	12291
	ENSG00000006283
	ENSMUSG00000020866
	O43497
	n/a
NM_001256324; NM_001256325; NM_001256326; NM_001256327; NM_001256328;
	NM_001256329; NM_001256330; NM_001256331; NM_001256332; NM_001256333; NM_001256334; NM_001256359; NM_001256360; NM_001256361; NM_018896; NM_198376; NM_198377; NM_198378; NM_198379; NM_198380; NM_198382; NM_198383; NM_198384; NM_198385; NM_198386; NM_198387; NM_198388; NM_198396; NM_198397
	NM_001112813; NM_001177888; NM_001177890; NM_009783
NP_001243253; NP_001243254; NP_001243255; NP_001243256; NP_001243257;
	NP_001243258; NP_001243259; NP_001243260; NP_001243261; NP_001243262; NP_001243263; NP_001243288; NP_001243289; NP_001243290; NP_061496; NP_938190; NP_938191; NP_938192; NP_938193; NP_938194; NP_938196; NP_938197; NP_938198; NP_938199; NP_938200; NP_938201; NP_938202; NP_938406
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Ca_v3.1 is a protein which in humans is encoded by the CACNA1G gene.^[5]^[6]^[7] It is one of the primary targets in the pharmacology of absence seizure.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006283 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020866 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".
^ Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. Bibcode:1998Natur.391..896P. doi:10.1038/36110. PMID 9495342. S2CID 4373283.
^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006283 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020866 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".

[pmid9495342-6] Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. Bibcode:1998Natur.391..896P. doi:10.1038/36110. PMID 9495342. S2CID 4373283.

[pmid16382099-7] Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.

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