CACNA1I

CACNA1I
Identifiers
Aliases	CACNA1I, Cav3.3, ca(v)3.3, calcium voltage-gated channel subunit alpha1 I
External IDs	OMIM: 608230; MGI: 2178051; HomoloGene: 69331; GeneCards: CACNA1I; OMA:CACNA1I - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,689,735 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	80,282,480 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; primary visual cortex; ; middle temporal gyrus; ; Brodmann area 46; ; entorhinal cortex; ; Region I of hippocampus proper; ; postcentral gyrus; ; superior frontal gyrus; ; glutes; ; right frontal lobe;
	Top expressed in
	striatum of neuraxis; ; olfactory bulb; ; superior frontal gyrus; ; visual cortex; ; primary visual cortex; ; cerebellum; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; hippocampus proper; ; hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated calcium channel activity; calcium channel activity; low voltage-gated calcium channel activity; voltage-gated ion channel activity; ion channel activity; protein binding; voltage-gated sodium channel activity;
Cellular component	voltage-gated calcium channel complex; integral component of membrane; membrane; plasma membrane;
Biological process	flagellated sperm motility; membrane depolarization during action potential; calcium ion import; regulation of ion transmembrane transport; ion transport; positive regulation of calcium ion-dependent exocytosis; sleep; calcium ion transmembrane transport; transmembrane transport; calcium ion transport; signal transduction; neuronal action potential; sodium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	8911
	239556
	ENSG00000100346
	ENSMUSG00000022416
	Q9P0X4
	n/a
	NM_001003406; NM_021096
	NM_001044308
	NP_001003406; NP_066919
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Ca_v3.3 is a protein which in humans is encoded by the CACNA1I gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100346 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022416 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit".
^ Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi:10.1016/S0304-3940(99)00319-5. PMID 10454147. S2CID 140208155.
^ Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100346 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022416 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit".

[pmid10454147-6] Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi:10.1016/S0304-3940(99)00319-5. PMID 10454147. S2CID 140208155.

[pmid16382099-7] Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.

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