CALCRL

CALCRL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3AQF, 3N7P, 3N7R, 3N7S, 4RWF
Identifiers
Aliases	CALCRL, CGRPR, CRLR, calcitonin receptor like receptor, LMPHM8
External IDs	OMIM: 114190; MGI: 1926944; HomoloGene: 21179; GeneCards: CALCRL; OMA:CALCRL - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	187,448,460 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	84,255,755 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; Achilles tendon; ; gallbladder; ; lower lobe of lung; ; right coronary artery; ; left coronary artery; ; smooth muscle tissue; ; subcutaneous adipose tissue; ; popliteal artery;
	Top expressed in
	left lung lobe; ; right lung; ; right lung lobe; ; vas deferens; ; iris; ; atrioventricular valve; ; carotid body; ; genital tubercle; ; endothelial cell of lymphatic vessel; ; semi-lunar valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; calcitonin receptor activity; signal transducer activity; protein binding; transmembrane signaling receptor activity; adrenomedullin receptor activity; calcitonin gene-related peptide receptor activity; adrenomedullin binding;
Cellular component	integral component of membrane; endosome; membrane; plasma membrane; integral component of plasma membrane; endoplasmic reticulum; lysosome; cytoplasm; adrenomedullin receptor complex; CGRP receptor complex;
Biological process	negative regulation of smooth muscle contraction; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; receptor internalization; cellular response to sucrose stimulus; heart development; cell surface receptor signaling pathway; angiogenesis; positive regulation of cell population proliferation; protein transport; negative regulation of inflammatory response; calcium ion transport; signal transduction; positive regulation of smooth muscle cell proliferation; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcitonin gene-related peptide receptor signaling pathway; adrenomedullin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10203
	54598
	ENSG00000064989
	ENSMUSG00000059588
	Q16602
	Q9R1W5
	NM_001271751; NM_005795; NM_001369434; NM_001369435
	NM_018782
	NP_001258680; NP_005786; NP_001356363; NP_001356364
	NP_061252
	Wikidata
View/Edit Human	View/Edit Mouse

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein; it is a receptor for calcitonin gene-related peptide.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064989 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059588 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (May 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064989 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059588 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8626685-5] Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (May 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J. Biol. Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.

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