CAMSAP2

CAMSAP2
Identifiers
Aliases	CAMSAP2, CAMSAP1L1, calmodulin regulated spectrin associated protein family member 2
External IDs	OMIM: 613775; MGI: 1922434; HomoloGene: 18927; GeneCards: CAMSAP2; OMA:CAMSAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	200,860,704 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	136,273,842 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; postcentral gyrus; ; optic nerve; ; endothelial cell; ; middle temporal gyrus; ; superior frontal gyrus; ; entorhinal cortex; ; Brodmann area 23; ; Brodmann area 46; ; Region I of hippocampus proper;
	Top expressed in
	otolith organ; ; utricle; ; superior cervical ganglion; ; trigeminal ganglion; ; zygote; ; substantia nigra; ; vestibular membrane of cochlear duct; ; secondary oocyte; ; Region I of hippocampus proper; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; calmodulin binding; microtubule minus-end binding; spectrin binding; protein binding;
Cellular component	cytoplasm; centrosome; microtubule; cytoskeleton; cytosol; microtubule end; microtubule minus-end; Golgi apparatus;
Biological process	regulation of organelle organization; neuron projection development; microtubule cytoskeleton organization; regulation of microtubule polymerization; regulation of dendrite development; axon development; regulation of Golgi organization; negative regulation of microtubule depolymerization; cytoplasmic microtubule organization;
	Sources:Amigo / QuickGO
Orthologs
	23271
	67886
	ENSG00000118200
	ENSMUSG00000041570
	Q08AD1
	Q8C1B1
	NM_001297707; NM_001297708; NM_203459; NM_001389638
	NM_001081360; NM_001347109; NM_001347110
	NP_001284636; NP_001284637; NP_982284
	NP_001334038; NP_001334039
	Wikidata
View/Edit Human	View/Edit Mouse

Calmodulin-regulated spectrin-associated protein family member 2 (CAMSAP2) is a protein in humans that is encoded by the CAMSAP2 gene.^[5] CAMSAP2 possesses a microtubule-binding domain near the C-terminal region where "microtubule interactions" occur. On the C-terminal regions, protein to protein interactions are accelerated by three coiled-coil domains, which function as molecular spacers.^[6] CAMSAP2 acts as a microtubule minus-end anchor and binds microtubules through its CKK domain. CAMSAP2 is necessary for the proper organization and stabilization of interphase microtubules. The protein also plays a role in cell migration.^[7] CAMSAP2 stabilizes and attaches microtubule minus ends to the Golgi through the AKAP9 complex and myomegalin. CLASP1 proteins are responsible for microtubule stability which are not required for the Golgi tethering. When no centromeres are present, AKAP9 and CAMSAP-2 dependent pathways of the microtubule minus ends become a dominant force and must exist in order to observe the maintenance of microtubule density.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118200 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041570 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "CAMSAP2 calmodulin regulated spectrin associated protein family member 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Archived from the original on 2024-02-27. Retrieved 2024-03-11.
^ Mao BP, Ge R, Cheng CY (January 2020). "Role of microtubule +TIPs and -TIPs in spermatogenesis - Insights from studies of toxicant models". Reproductive Toxicology. 91: 43–52. doi:10.1016/j.reprotox.2019.11.006. PMID 31756440. Archived from the original on 2024-04-15. Retrieved 2024-04-15.
^ Baines AJ, Bignone PA, King MD, Maggs AM, Bennett PM, Pinder JC, et al. (September 2009). "The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins". Molecular Biology and Evolution. 26 (9): 2005–2014. doi:10.1093/molbev/msp115. PMID 19508979. Archived from the original on 2022-06-15. Retrieved 2022-09-29.
^ Wu J, de Heus C, Liu Q, Bouchet BP, Noordstra I, Jiang K, et al. (October 2016). "Molecular Pathway of Microtubule Organization at the Golgi Apparatus". Developmental Cell. 39 (1): 44–60. doi:10.1016/j.devcel.2016.08.009. PMID 27666745. Archived from the original on 2024-04-15. Retrieved 2024-04-15.
^ "AlphaFold Protein Structure Database". alphafold.ebi.ac.uk. Archived from the original on 2022-10-01. Retrieved 2024-04-12.
^ Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, et al. (January 2022). "AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models". Nucleic Acids Research. 50 (D1): D439–D444. doi:10.1093/nar/gkab1061. PMC 8728224. PMID 34791371. Archived from the original on 2024-04-15. Retrieved 2024-04-15.
^ Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, et al. (August 2021). "Highly accurate protein structure prediction with AlphaFold". Nature. 596 (7873): 583–589. Bibcode:2021Natur.596..583J. doi:10.1038/s41586-021-03819-2. PMC 8371605. PMID 34265844.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118200 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041570 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "CAMSAP2 calmodulin regulated spectrin associated protein family member 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Archived from the original on 2024-02-27. Retrieved 2024-03-11.

[6] Mao BP, Ge R, Cheng CY (January 2020). "Role of microtubule +TIPs and -TIPs in spermatogenesis - Insights from studies of toxicant models". Reproductive Toxicology. 91: 43–52. doi:10.1016/j.reprotox.2019.11.006. PMID 31756440. Archived from the original on 2024-04-15. Retrieved 2024-04-15.

[7] Baines AJ, Bignone PA, King MD, Maggs AM, Bennett PM, Pinder JC, et al. (September 2009). "The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins". Molecular Biology and Evolution. 26 (9): 2005–2014. doi:10.1093/molbev/msp115. PMID 19508979. Archived from the original on 2022-06-15. Retrieved 2022-09-29.

[8] Wu J, de Heus C, Liu Q, Bouchet BP, Noordstra I, Jiang K, et al. (October 2016). "Molecular Pathway of Microtubule Organization at the Golgi Apparatus". Developmental Cell. 39 (1): 44–60. doi:10.1016/j.devcel.2016.08.009. PMID 27666745. Archived from the original on 2024-04-15. Retrieved 2024-04-15.

[9] "AlphaFold Protein Structure Database". alphafold.ebi.ac.uk. Archived from the original on 2022-10-01. Retrieved 2024-04-12.

[10] Varadi M, Anyango S, Deshpande M, Nair S, Natassia C, Yordanova G, et al. (January 2022). "AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models". Nucleic Acids Research. 50 (D1): D439–D444. doi:10.1093/nar/gkab1061. PMC 8728224. PMID 34791371. Archived from the original on 2024-04-15. Retrieved 2024-04-15.

[11] Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, et al. (August 2021). "Highly accurate protein structure prediction with AlphaFold". Nature. 596 (7873): 583–589. Bibcode:2021Natur.596..583J. doi:10.1038/s41586-021-03819-2. PMC 8371605. PMID 34265844.

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