CARD (domain)

Caspase recruitment domain
Structure of the RAIDD CARD.[1]
Identifiers
SymbolCARD
PfamPF00619
InterProIPR001315
SMARTSM00114
PROSITEPS50209
SCOP23crd / SCOPe / SUPFAM
CDDcd01671
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1c15​, 1cww​, 1cy5​, 1dgn​, 1z6t​, 2a5y​, 2p1h​, 2ygs​, 3crd​, 3ygs
Caspase recruitment domain, IPS1/RIG-I
Identifiers
SymbolCARD_2
PfamPF00619
InterProIPR031964
SCOP22lwd / SCOPe / SUPFAM
CDDcd08789
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Caspase recruitment domains, or caspase activation and recruitment domains (CARDs), are interaction motifs found in a wide array of proteins, typically those involved in processes relating to inflammation and apoptosis. These domains mediate the formation of larger protein complexes via direct interactions between individual CARDs. CARDs are found on a strikingly wide range of proteins, including helicases, kinases, mitochondrial proteins, caspases, and other cytoplasmic factors.

  1. ^ Chou JJ, Matsuo H, Duan H, Wagner G (July 1998). "Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment". Cell. 94 (2): 171–80. doi:10.1016/S0092-8674(00)81417-8. PMID 9695946. S2CID 16499945.