CBX1

CBX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3Q6S, 2FMM, 3F2U
Identifiers
Aliases	CBX1, CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta, chromobox 1
External IDs	OMIM: 604511; MGI: 105369; HomoloGene: 89116; GeneCards: CBX1; OMA:CBX1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,101,478 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	96,699,466 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; secondary oocyte; ; tendon of biceps brachii; ; internal globus pallidus; ; C1 segment; ; endothelial cell; ; optic nerve; ; amniotic fluid; ; amygdala;
	Top expressed in
	otic placode; ; saccule; ; Gonadal ridge; ; genital tubercle; ; mandibular prominence; ; tail of embryo; ; abdominal wall; ; maxillary prominence; ; otic vesicle; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone methyltransferase binding; enzyme binding; chromatin binding; protein binding; protein homodimerization activity; identical protein binding;
Cellular component	chromocenter; pericentric heterochromatin; chromatin; spindle; chromosome, centromeric region; male pronucleus; female pronucleus; nucleoplasm; nucleus; site of DNA damage;
Biological process	negative regulation of transcription, DNA-templated; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	10951
	12412
	ENSG00000108468
	ENSMUSG00000018666
	P83916
	P83917
	NM_006807; NM_001127228
	NM_007622; NM_001362560; NM_001362561; NM_001362563; NM_001362564
	NP_001120700; NP_006798
	NP_031648; NP_001349489; NP_001349490; NP_001349492; NP_001349493
	Wikidata
View/Edit Human	View/Edit Mouse

Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108468 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018666 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Furuta K, Chan EK, Kiyosawa K, Reimer G, Luderschmidt C, Tan EM (Jun 1997). "Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis". Chromosoma. 106 (1): 11–9. doi:10.1007/s004120050219. PMID 9169582. S2CID 33460511.
^ "Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108468 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018666 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9169582-5] Furuta K, Chan EK, Kiyosawa K, Reimer G, Luderschmidt C, Tan EM (Jun 1997). "Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis". Chromosoma. 106 (1): 11–9. doi:10.1007/s004120050219. PMID 9169582. S2CID 33460511.

[entrez-6] "Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )".

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